Full size image Fig. 8: Model of MRNIP condensates function in DNA damage sensing and end resection. Full size image After DSB formation, a series of DNA repair factors are recruited and concentrated at damaged DNA lesions to form DNA repair centers31. These factors form highly concentrated fo...
The membrane-bound protein programmed cell death receptor 1 (PD-1) has been implicated in a second resistance mechanism. The protein is located primarily on the immune system’s T cells. When the protein binds its ligand, PD-L1, T cells are inactivated either through anergy or by undergoing ...