Together, these reports supported our view that lamin A may be part of the radiation response. Lastly, ATM activation itself through oxidative (ionizing) stress is achieved via cysteines. Howes et al. structurally resolved the ROS-activated form of ATM and it is a disulfide-bound dimer with ...
Poly (ADP-ribose) polymerase (PARP) inhibitors mechanism of action in homologous recombination (HR) proficient and deficient cells. When the DNA is damaged, leading to the formation of single-strand breaks (SSBs), the base excision repair (BER) pathway repairs these SSBs, mostly through the inv...
TRF2 is the master shelterin factor: its depletion or the expression of a dominant negative form of TRF2, lacking the Myb and basic domains, trigger telomere end-to-end fusions. These chromosomal structures are a consequence of the activity of the DNA ligase IV and of the Non-Homologous End...
A simplified view of the cellular response to DNA damage. Single and double stranded DNA breaks signal through the sensors (MRN and 9-1-1) shown in purple, mediators (H2AX, BRCA1, MDC1, 53BP1) shown in blue, signal transducing kinases (ATM, ATR) shown in yellow, effector kinases (CHK...
(CtIP) binds to BRCA1 and nucleases EXO1, further interacts with MRN and excises the DSB ends together, resulting in the formation of single-stranded DNA (ssDNA). The excised DNA ends are coated with hyperphosphorylated ssDNA -binding protein A (RPA) to form a nucleoprotein filament. The ...
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Nowadays, the information society has stepped into a new era, in which the mobile Internet, cloud computing, big data, and Internet of Things are the leading technologies [1]. The big data has main features: volume, variety, velocity, and value [2]. Thus, future wireless networks are requ...
Molecular modifications of lactylation in cancer. a) Autophagy in cells: Lactylation of DCBLB1 can inhibit the degradation of key enzymes in the pentose phosphate pathway, thereby extending their existence, while also inhibiting its own degradation to form a positive feedback loop. In contrast, ...
found to have a translocation that generated a fusion protein between 53BP1 and the platelet-derived growth factor (PDGF; [48]). Because, in this scenario, PDGF tyrosine kinase activity depends on the ability of its fusion partner sequences to form oligomers, it was proposed that 53BP1 coul...
The former is programmed cell death, a form of cellular suicide that removes damaged cells from the cell population [24]; the latter is a natural irreversible cell cycle arrest, induced by DDR. It remains unclear what determines the choice between apoptosis and senescence, but determinants may ...