MRN complex is an essential effector of DNA damage repairMRN蛋白复合物是一个重要的DNA损伤修复效应因子DNA damage repairMRE11-RAD50-NBS1 (MRN) complexHomologous recombinationNon-homologous end joiningGenome stability can be threatened by both endogenous and exogenous agents. Organisms have evolved ...
Mechanism of BLM recruitment to the DSBs and its effect on DNA repair. In the recruitment phase, MRN complex is recruited to the AsiSI-induced DSBs (a), which in turn recruits ATM (b). Chromatin-bound E3 ligase RNF8 polyubiquitylates BLM (red line, red dots representing ubiquitin residues)...
概要: 关键词组: DNA损伤修复;MRE11-RAD50-NBS1(MRN)蛋白复合物;同源重组修复;非同源末端连接修复 作者: Shan QIU, Jun HUANG 本文引用格式: Shan QIU, Jun HUANG, 2021. MRN complex is an essential effector of DNAdamage repair. Journal of Zhejiang University-Science B (Biomedicine & Biotechnology)...
MRN Complex Antibody Sampler Kit 中文名: 中文别名: CBNumber: CB65660650 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商15 MRN Complex Antibody Sampler Kit化学性质 安全信息 MRN Complex Antibody Sampler Kit性质、用途与生产工艺 ...
The rapid recognition of DNA double-strand breaks (DSBs) by the MRE11/RAD50/NBS1 (MRN) complex is critical for the initiation of DNA damage response and DSB end resection. Here, we show that MRN complex interacting protein (MRNIP) forms liquid-like conde
这项研究发现DNA损伤应答途径中的重要因子MRN(MRE11-RAD50-NBS1)复合体可与新蛋白MMAP(Mitosis-specific MRN associated protein)形成分裂期特异的mMRN复合体(mitosis-specific MMAP–MRN complex),并与有丝分裂的重要激酶PLK1、微管解聚酶KIF2A相互作用,且该复合体可以在分裂期的纺锤体上与KIF2A共定位。MMAP可以与...
这项研究发现DNA损伤应答途径中的重要因子MRN(MRE11-RAD50-NBS1)复合体可与新蛋白MMAP(Mitosis-specific MRN associated protein)形成分裂期特异的mMRN复合体(mitosis-specific MMAP–MRN complex),并与有丝分裂的重要激酶PLK1、微管解聚酶KIF2A相互作用,且该复合体可以在分裂期的纺锤体上与KIF2A共定位。MMAP可以与...
[关键词]MRN复合物;DNA双链损伤修复;共济失调-毛细血管扩张样疾病;Nijmegen断裂综合征[中图分类号]Q75LQ24[文献标识码]AAdvancesinStructureandFunctionofMRNComplexHEXiang,ZHONGHuiBeijingInstituteofBiotechnology,Beijing100850,China[Abstract]TheMRNcomplexconstitutesofMRE11,NBS1andRAD50,andthedeficiencyofMRE11andNBS1...
英文名称:MRN Complex Antibody Sampler Kit 英文同义词:MRN Complex Antibody Sampler Kit CAS号: 分子式: 分子量:0 EINECS号: 信息错误报告 您的Email: 按国家浏览MRN Complex Antibody Sampler Kit国外供应商中国供应商 MRN Complex Antibody Sampler Kit推荐供应商 ...
Cells depleted of MRNIP display impaired chromatin loading of the MRN complex, resulting in reduced DNA end resection and defective ATM-mediated DNA damage signaling, a reduced ability to repair DNA breaks, and radiation sensitivity. Finally, we show that MRNIP phosphorylation on serine 115 leads ...