The nuclease activity of the MRN complex is responsible for DNA end resection, which guides DNA repair to HR in the presence of sister chromatids. The MRN complex is also involved in NHEJ, and has a species-specific role in hairpin repair. This review focuses on the structure of the MRN ...
MRN complex is recruited to the AsiSI-induced DSBs (a), which in turn recruits ATM (b). Chromatin-bound E3 ligase RNF8 polyubiquitylates BLM (red line, red dots representing ubiquitin residues). The kinase activity of ATM (brown lines) is essential for the BLM recruitment process...
2009. High resolution imaging of changes in the structure and spatial organization of chromatin, gamma-H2A.X and the MRN complex within etoposide-induced ... Graham,Dellaire,Rosemarie,... - 《Cell Cycle》 被引量: 125发表: 2009年 On the influence of the vertical density structure on the dy...
These phosphorylations activate downstream protein kinase, alter protein-protein interactions, modify the capacity of proteins to bind to chromatin and alter chromatin structure to regulate various cellular processes. However, it is evident that phosphorylation of members of the MRN complex is responsible...
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complex is responsible for DNA end resection,which guides DNA repair to HR in the presence of sister chromatids.The MRN complex is also involved in NHEJ,and has a species-specific role in hairpin repair.This review focuses on the structure of the MRN complex and its function in DNA damage ...
Lee J-H, Goodarzi AA, Jeggo PA, Paull TT (2010b) 53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J 29:574–585Lee JH, Goodarzi AA, Jeggo PA, Paull TT. 2010. 53BP1 promotes ATM activity through direct interactions with the MRN complex . EMBO J. ...