与健康的 MRL/MpJ 小鼠相比,MRL/MpJ-Faslpr/lpr小鼠泪道和鼻腔黏膜上皮下的淋巴组织更多,泪道相关淋巴组织(LDALT)和鼻咽相关淋巴组织(NALT)是头部主要的 MALTs。在鼻黏膜中,MRL/MpJ-Faslpr/lpr小鼠的 NALT 更大,非纤毛上皮细胞和杯状细胞更多,且 NALT 内增殖细胞也更多。部分 MRL/MpJ-Faslpr/lpr小鼠的 LDAL...
MRL/MpJ-Faslpr/J 品系货号:000485 | 通用名称:MRL-Ipr 又名:淋巴细胞增殖小鼠、MRL-lpr 小鼠 此品系通常称为 MRL-lpr 或lpr 突变品系。此品系为淋巴细胞增殖自发突变 ( Faslpr) 纯合小鼠,表现出全身自身免疫、异常 T 细胞增殖相关巨大淋巴结病、关节炎和免疫复合物肾小球肾炎。此品系小鼠可用作系统性红斑狼疮...
MRL.MpJ‐Faslpr mouseObjectives Previous studies of decreased cochlear DNA binding in autoimmune mice suggested that antibodies against a cochlear cell surface DNA receptor cause autoimmune hearing loss. However, the presence of a cochlear DNA receptor has not been determined. Therefore, ...
These findings suggest that action in MRL/MpJ-(lpr) is gender dependent, probably through modulation and inhibition of sex hormones. 展开 关键词: questionnaire severe short stature severe GHD idiopathic GHD DOI: 10.1210/en.2005-0648 被引量: 48 ...
Many different adhesion molecules are thought to participate in the development of SLE; however, few studies have directly examined the contributions of these proteins. Here we demonstrate that LFA-1 plays an essential role in the development of lupus in MRL/MpJ- Fas lpr mice. Mice deficient in...
Aldo- sterone (Mineralocorticoid) equivalent to pred- nisolone (Glucocorticoid) in Reversing hearing loss in MRL/MpJ-faslpr autoimmune mice. La- ryngoscope 2000; 110: 1902-1906.Trune DR, Kempton JB, Kessi M. Aldosterone (min- eralocorticoid) equivalent to prednisolone (glucocorti- coid) ...
Shoshan Y, Mevorach D: Accelerated autoimmune disease in MRL/MpJ- Fas(lpr) but not in MRL/MpJ following immunization with high load of syngeneic late apoptotic cells. Autoimmunity 2004, 37:103-109.Accelerated Autoimmune Disease in MRL/MpJ-Faslpr but not in MRL/MpJ Following Immunization with...
IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice . J Immunol 2012; 188 :1656–67.Rankin AL, Guay H, Herber D, Bertino SA, Duzanski TA, Carrier Y, Keegan S, Senices M, Stedman N, Ryan M, Bloom L, Medley...
These findings confirm that melatonin action in MRL/MpJ-Fas lpr mice could be gender-dependent through modulation of sex hormones. 展开 关键词: estradiol melatonin MRL/MpJ-Fas<SUP> lpr </SUP> mice systemic lupus erythematosus testosterone
We investigated the effects of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) on the MRL/MpJ-Faslpr (MRL/lpr) murine model of SLE. We found that treating MRL/lpr mice with 300 ng 1,25(OH)2D3/day completely prevents proteinuria. Renal changes induced by 1,25(OH)2D 3 treatment ...