MRL/MpJ-Faslpr/J 品系货号:000485 | 通用名称:MRL-Ipr 又名:淋巴细胞增殖小鼠、MRL-lpr 小鼠 此品系通常称为 MRL-lpr 或lpr 突变品系。此品系为淋巴细胞增殖自发突变 ( Faslpr) 纯合小鼠,表现出全身自身免疫、异常 T 细胞增殖相关巨大淋巴结病、关节炎和免疫复合物肾小球肾炎。此品系小鼠可用作系统性红斑狼疮...
Ultrastructural pathology in the stria vascularis of the MRL-Fasl (lpr) mouse. Hear. Res. 131 (1 - 2), 22 - 28.Ruckenstein MJ, Keithley EM, Bennett T, Powell HC, Baird S, Harris JP. Ultrastructural pathology in the stria vascularis of the MRL-Fas lpr mouse. Hear. Res. 1999a; ...
选取22周龄雌性B6.MRL—Faslpr/J狼疮小鼠3O只,留gx24h尿液及外周 血后处死,取脾脏组织进行匀浆过滤,分别检测各小鼠24h尿蛋白量、血清中抗核抗体(ANA)和抗ds—DNA抗 体水平,流式细胞仪检测小鼠脾脏Treg细胞及淋巴细胞。应用Pearson对Treg细胞比例与24h尿蛋白量、血清 ...
Background/Aim: Pathological accumulation of the extracellular matrix component hyaluronan (HA) occurs in the kidney cortex in immune-system mediated tissue injury. The purpose of the present study was to examine the pattern of HA deposition and the mechanisms of HA synthesis in the MRL-Faslpr mo...
Pathological accumulation of the extracellular matrix component hyaluronan (HA) occurs in the kidney cortex in immune-system mediated tissue injury. The purpose of the present study was to examine the pattern of HA deposition and the mechanisms of HA synthesis in the MRL-Fas(lpr) mouse model of...
may be another reason for severe inflammation. The increase of FoxP3+T cells detected in the kidney seems unable to dampen the massive kidney inflammation. Interestingly, lymphadenopathy was reduced in MRL-Faslpr/KSRP−/−mice. Altogether, KSRP appears to have a complex role in immune ...
B6.MRL—Fas lpr／J狼疮小鼠脾脏组织中Th17细胞比例及其与病情的相关性
of exogenous FasL-expression, we established a simple but clear mouse model on which we performed liver transplantation between Fas-mutant mice (MRL-lpr/lpr) and wild-type mice (MRL+/+).Methods.The controls were nontransplanted wild-type (group 1) and MRL-lpr/lpr(group...
MRL/MpJ-Faslpr/lpr/J (MRLlpr) mice develop lupus-like disease manifestations in an IL-21-dependent manner. IL-21 is a pleiotropic cytokine that can influen... Rankin,L Andrew - 《Journal of Immunology》 被引量: 103发表: 2012年 Modulation of renal disease in MRL/lpr mice by pharmacologic...