—— 基于 MRL/MpJ-Faslpr/lpr小鼠的探秘 《Cell and Tissue Research》:Altered morphology of mucosa-associated lymphoid tissues and epithelium in the nasal cavity and lacrimal apparatus in autoimmune disease-prone MRL/MpJ-Faslpr/lpr mice 编辑推荐: 为探究自身免疫疾病、黏膜上皮和黏膜相关淋巴组织(MALTs)...
B lymphocytes mediate Fas-dependent cytotoxicity in MRL/lpr mice. J Leukoc Biol. 2005;78:1052–9.Bonardelle D, Benihoud K, Kiger N, Bobe P: B lymphocytes mediate Fas-dependent cytotoxicity in MRL/lpr mice. J Leukoc Biol 2005, 78: 1052–1059....
may be another reason for severe inflammation. The increase of FoxP3+T cells detected in the kidney seems unable to dampen the massive kidney inflammation. Interestingly, lymphadenopathy was reduced in MRL-Faslpr/KSRP−/−mice. Altogether, KSRP appears to have a complex role in immune ...
It has been exciting for scientists to postulate all sorts of derangements to explain the numerous observations regarding the disease of MRL-lpr/lpr mice. Until recently, our imaginations have had almost free reign, unconstrained by any true knowledge. Now, however, it has been found that the ...
This difference was also observed in the MRL-Faslpr/lprmice in vivo, where the prototypic class R INH-ODN was more effective in curtailing abnormal autoantibody secretion and prolonging survival. Conclusions The increased potency of class R INH-ODNs for autoreactive B cells and dendritic cells ...
Cpn10 entirely prevented cutaneous lupus lesions as compared to vehicle-treated mice. Cpn10 also suppressed lupus nephritis as evident from serum creatinine levels, albuminuria and the scores of disease activity and chronicity. Autoimmune lung disease was unaffected by Cpn10 treatment while overall surv...
Longdan Xiegan Tang has immunomodulatory effects on CD4+CD25+ T cells and attenuates pathological signs in MRL/lpr mice Longdan Xiegan Tang (LXT) is a Chinese herbal medicine that is prescribed as an anti-inflammatory aid, a hepato-protectant, and an immunostimulant. In this... HH Chang,...
urinaryprotein,serumantinuclearantibody(ANA)andanti—ds—DNAantibodyofthemiceweredetected,flowc~ometryWas usedtodetectsplenicTregcellsandlymphocytesofthem i ce.Thecorrelationoftheproportionof Tregcels 山thelevels of24一hoururinaryprotein.serumANAandanti—ds-DNAantibodywasanalyzedbyPearsoncorrelation.Results ...
Susceptibility to severe lupus in MRL-Fas(lpr) mice requires not only the lpr mutation but also other predisposing genes. Using (MRL-Fas(lpr) x B6-Fas(lpr)... ML Santiago-Raber,MK Haraldsson,AN Theofilopoulos,... - 《Journal of Immunology》 被引量: 96发表: 2007年 The -346T polymorp...
1. B lymphocytes mediate Fas-dependent cytotoxicity in MRL/lpr mice. [J] . Bobe P Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2005,第5期 机译:B淋巴细胞在MRL / lpr小鼠中介导Fas依赖性细胞毒性。 2. Liver is a possible site for the proliferatio...