另外需要注意的是骨髓增生不良可能会影响MRD定量检测,有些检测方案需要在血细胞计数恢复正常之后再送检MRD[18]。 (5) 《急性淋巴细胞白血病微小残留病检测与临床解读中国专家共识(2023年版)》[15]中MRD检测时机的建议:①初诊ALL患者:在初始治疗前,应...
Fasching K,Konig M,Hettinger K,et al.MRD levels during the first months of treatment indicate relapses in children with t(12;21)-positive ALL.Leukemia. 2000Fasching K, Konig M, Hettinger K, et al. MRD levels during the first months of treatment indicate relapses in children with t(12;...
这一序贯双检策略显示出较高的阳性预测值(positive predictive value,PPV,78.6%),只需对17.9%(28/156)的患者进行1个月血浆重评,不仅兼顾临床采血的便利性,同时提升landmark检测准确性。 Longitudinal MRD疾病监测 共有110例患者的347个...
Blinatumomab (Blincyto) has been granted full approval for the treatment of adult and pediatric patients with CD19-positive B-cell precursor acute lymphoblastic leukemia (B-ALL) who are in first or second complete remission and who have minimal residual disease (MRD) of at least 0.1%.1 The F...
In the experimental arm, maintenance therapy was based on MRD status; all patients initially received 1800 mg of daratumumab once every 4 weeks plus 10 mg of lenalidomide per day for a minimum of 2 years. Patients who were MRD positive continued DR. Those who were MRD negative for at ...
The study excluded patients who were MRD positive at the time of screening; those with plasma cell leukemia or another disorder of plasma cell neoplasm; patients receiving any other treatment for multiple myeloma except for bisphosphonates; those who underwent prior solid organ transplant or had a ...
treatment. Of these, 60 patients were enrolled (Figure 1).Figure 1. Summary of Participant Enrollment and Study GroupsGroup A included patients who exhibited no positive molecular indicators and persisted in their treatment hiatus; group B, patients who initiated treatment following the indication of...
Key experts in hematology oncology discuss the use of MRD status to assess therapeutic response and guide treatment decisions in patients with relapsed/refractory ALL.
·临床研究·MRD监测对儿童B系急性淋巴细胞性白血病疗效评估的意义叶启东,顾龙君,汤静燕,薛惠良,陈静,潘慈,陈静,董璐,周敏,蒋黎敏(上海交通大学医学院附属上海儿童医学中心血液肿瘤科,上海 200127) [摘要] 目的 研究监测微小残留白血病(MRD)在B系急性淋巴细胞白血病(ALL)患儿治疗中的作用。方法 回顾性研究了2001年9...
years, early relapse, shortened complete remission duration and positive minimal residue disease ( MRD ) status after treatment. SLC 2A5 overexpression at ... Zhao PanHuang JingcaoZhang DanZhang DanfengWang FangfangQu YingGuo TingtingQin YuWei JinNiu TingZheng Yuhuan - 《British Journal of Haematolo...