首先,I类和II类Mpox病毒株的差异对公共卫生应对具有重要意义。根据WHO的定义,I类Mpox病毒株(clade 1b)在传播速度和致死率方面均高于II类病毒株(clade 2)。在2022年美国疫情中,II类病毒株的死亡率约为0.2%,而I类病毒株的死亡率则高达3.9%。这种差异意味着,公共卫生部门在应对I类病毒株时需要采取更为严格和迅...
然而,尽管美国的mpox风险相对较低,公共卫生机构仍需关注高风险群体的健康状况。CDC的评估强调,尽管在DRC有记录的性传播病例,但美国目前没有clade I mpox的已知病例,且大多数MSM在2022年疫情后已获得一定的免疫力,这可能会降低感染风险。CDC还提到,MSM群体在2022年疫情中经历了行为适应,这可能会在未来疫情中再次出现...
The clade 1 mpox variant, responsible for the majority of current infections, has been detected in neighboring DRC countries, and in an increasing number of non-African countries where this variant is not known to be endemic.2,3To date, only one case outside the endemic region has been con...
“At present, we are seeing uncontrolled transmission of clade 1b in eastern DRC and Burundi, but to a lesser extent in other parts of East Africa. While there is some international spread, we do not yet expect a large outbreak outside the epicenter in East Africa. However, this situation...
A virulent mpox outbreak in the Democratic Republic of the Congo (DRC) involving clade I viruses began in 2023 and continues into 2025. A high proportion of cases have occurred in children aged younger than 15 years, with a case-fatality rate of 10% in infants and young children. Person-...
A virulent mpox outbreak in the Democratic Republic of the Congo (DRC) involving clade I viruses began in 2023 and continues into 2025. A high proportion of cases have occurred in children aged younger than 15 years, with a case-fatality rate of 10% in infants and young children. Person-...
, placebo-controlled, double-blind trial evaluating the safety and efficacy of oral tecovirimat for the treatment of mpox was completed; preliminary results indicated that tecovirimat did not reduce the duration of mpox lesions among 597 children and adults with clade I MPXV in the DRC....
, placebo-controlled, double-blind trial evaluating the safety and efficacy of oral tecovirimat for the treatment of mpox was completed; preliminary results indicated that tecovirimat did not reduce the duration of mpox lesions among 597 children and adults with clade I MPXV in the DRC....
clade-specific testing. This will assist with national surveillance efforts. Specimens collected from patients who traveled to DRC should be sent to CDC as expeditiously as possible. Some non-CDC laboratories may also have options (e.g., molecular testing or genetic sequencing) available for clade...
As mentioned above, clade 1 occurs regularly in the DRC. However, the current outbreak has become more widespread than any other previous outbreak (CDC, 2024f). As of August 2024, the WHO declared a Public Health Emergency of International Concern (PHEIC) because of the threat that the clade...