The 4T1 cell line, derived from BALB/cfC3H mice, represents a TNBC subtype of BCa lacking estrogen receptor (ER), progesterone receptor (PR), and human endothelial growth factor (HER2) expression. This cell line closely resembles Stage IV and advanced basal phenotypes in human BCa with ...
TNBC genO‑BRGSF‑HIS model is donor-independent and recapitulates TNBC patients' TME 2-week-old genO‑BRGSF‑HIS mice were injected with hFlt3L/Fc prior to MDA-MB-231 inoculation (DO). Tumor growth was followed over 30 days (A), and tumors (400-500m3) were collected and analyzed...
progesterone receptor (PR) and the human epidermal growth factor receptor 2 (HER2). TNBC is the most aggressive, metastatic and remarkably drug-resistant subtype of breast cancer particularly due to the lack of specific and targeted therapeutics [1]. Global cases...
Establishment ofTNBCmetastatic model The mammalian fat pads (MFPs) of 5–7 week-old female BALB/c nude mice (Sun Yat-sen University, Guangzhou, Guangdong, China) were injected with MDA-MB-231 cells (2.5 × 107ml−1). After 3 weeks, breast cancer tissues were resected underPentobarbital ...
In the past, we showed that systemic administration of mHAdLyp.sT inhibited bone metastases in a human TNBC cell line (MDA-MB-231) immunodeficient mouse model. Therefore, we applied mHAdLyp.sT alone and together with immune checkpoint inhibitors (ICIs) to test their treatment efficacy in this...
To explore the possibility of using selinexor as an effective treatment for TNBC brain metastasis, a mouse model was established and tested.Methods: TNBC cell line HCC1806 (ATCC# CRL-2335) was transformed with RediFect Red-Fluc-Puromycin and selected using puromycin to generate HCC1806-Fluc ...
expression of the stem cell gene signature was interrogated in two large independent TNBC cohorts, tumours with an activated stem cell signature showed a higher propensity to relapse in the first years after diagnosis in comparison to TNBC with lower activation scores for the stem cell gene ...
epigallocatechin-3-gallate (EGCG) significantly inhibited PRODH and its regulated proteins, such as alpha-smooth muscle actin (alpha-SMA) expression in TNBC cells. These findings support the targeting of the PRODH signaling pathway as a potential therapeutic strategy in preventing cancer cell m...
A later study from the same group using PDX from triple negative breast cancer (TNBC) identified a tumour-specific signature predicting the presence of CTC clusters (Thangavel et al., 2019). In a similar fashion, Torphy et al. (2014) used (PDX) mouse models of pancreatic ductal ...
iMN041 was also tested in xenograft models of human cancer, the TNBC cell line DU4475, ccRCC cell lines 786-O and Caki-1, and pancreatic Table 2 Pharmacokinetics of iMN013 released from iMN041 formulated in FS-14 or FS-19. Where: Cmax is the maximum concentration, Tmax is the ...