PIM172, and PIM262). Scale bar = 200 μM for PIM056, PIM010, and PIM077. 300 μM for PIM228 and all TNBC PDXs.bRepresentative graphs show luminescence-based assays of cell viability with TRIM24 degrader
The reason for thisaggressive phenotype is currently the focus of extensive research.Methods: To understand the mechanistic basis for the aggressiveness of TNBC, we produced a stablecell line by transfecting 4T1 cells with empty vector control and sorted for cells that do not express HER2, ER ...
Tumor microenvironment composition is shaped by tumor cell line-derived xenograft subtype and tumor burden in BRGSF-HIS mice TME composition in BRGSF-HIS mice Nov 2024 Assessment of γδ T-cell therapies in humanized mice BRGSF-HIS for γδ T-cell therapies ...
Establishment ofTNBCmetastatic model The mammalian fat pads (MFPs) of 5–7 week-old female BALB/c nude mice (Sun Yat-sen University, Guangzhou, Guangdong, China) were injected with MDA-MB-231 cells (2.5 × 107ml−1). After 3 weeks, breast cancer tissues were resected underPentobarbital ...
expression of the stem cell gene signature was interrogated in two large independent TNBC cohorts, tumours with an activated stem cell signature showed a higher propensity to relapse in the first years after diagnosis in comparison to TNBC with lower activation scores for the stem cell gene ...
In the past, we showed that systemic administration of mHAdLyp.sT inhibited bone metastases in a human TNBC cell line (MDA-MB-231) immunodeficient mouse model. Therefore, we applied mHAdLyp.sT alone and together with immune checkpoint inhibitors (ICIs) to test their treatment efficacy in this...
A mouse model for triple-negative breast cancer tumor-initiating cells (TNBC-TICs) exhibits similar aggressive phenotype to the human disease Background Triple-negative breast cancer (TNBC) exhibit characteristics quite distinct from other kinds of breast cancer, presenting as an aggressive disea... ...
Triple-negative breast cancer (TNBC) has a faster rate of metastasis compared to other breast cancer subtypes, and no effective targeted therapies are curr
TNBC patients face limited therapeutic options; chemotherapy is standard of care. TNBCs are a heterogeneous class and can be categorized into distinct subtypes: basal-like (1 and 2), claudin-low, immunomodulatory, mesenchymal-like, mesenchymal stem-like, and luminal androgen receptor positive3,4. ...
C3Tag DCIS disease state signatures are enriched in Human TNBC and Basal-like DCIS We next sought to evaluate the C3Tag scRNAseq derived gene signatures on human DCIS specimens. To achieve this, we curated multiple published gene expression datasets of human DCIS and performed PAM50 subtyping on...