Single-cell RNA sequencing analysis of human spinal cord microglia reveals a subpopulation with a disease-related transcriptional signature. Our data provide a detailed analysis of transcriptional states of mouse and human spinal cord microglia, and identify a link between ApoE and chronic pain in ...
Single-cell RNA sequencing data can unveil the molecular diversity of cell types. Cell type atlases of the mouse spinal cord have been published in recent years but have not been integrated together. Here, we generate an atlas of spinal cell types based on single-cell transcriptomic data, unify...
spinal cord, including transcriptional differences that correlate with electrophysiologically and spatially distinct motor pools. We also provide evidence for a novel transcriptional subpopulation of skeletal motor neuron (γ*). Collectively, these data provide a single-cell transcriptional atlas (http://...
Single-cell RNA sequencing analysis of human spinal cord microglia reveals a subpopulation with a disease-related transcriptional signature. Our data provide a detailed analysis of transcriptional states of mouse and human spinal cord microglia, and identify a link between ApoE and chronic pain in ...
we allocated the combinatorial expression of a curated marker gene list that is used to define different domains of progenitors in single-cell RNA-seq45to the spinal cord spots, including dorsal gene sets (D) by combinatorial marker expression of roof plate (RP) and dp1–dp6, medial gene set...
Single cell RNA analysis of the left–right organizer transcriptome reveals potential novel heterotaxy genes Article Open access 01 July 2023 Main Embryonic development necessitates the precise timing and location of numerous molecular, cellular and tissue-level processes1,2,3,4,5. These events are...
We performed single-cell RNA sequencing on the mouse embryonic medial ganglionic eminence (MGE), the major birthplace for CINs, and on MGE-like cells differentiated from embryonic stem cells. Two distinct cell types were identified as proliferating neural progenitors and immature neurons, both of ...
Macroglia (astrocytes and oligodendrocytes) are required for normal development and function of the central nervous system, yet many questions remain about their emergence during the development of the brain and spinal cord. Here we used single-cell/single-nucleus RNA sequencing (scRNA-seq/snRNA-seq...
Single-cell RNA sequencing identified and characterized a unique group of pathogen-activated Treg cells that constitute 32.6% of the pathogen-activated maternal Treg population. Our study establishes a new preclinical parasite-mimicking MIA model and suggests therapeutic potential of adoptive Treg cell ...
Cellular and Molecular Neurobiology (2023) Single-cell RNA sequencing reveals Nestin+ active neural stem cells outside the central canal after spinal cord injury Muya Shu Xiaoyu Xue Jianwu Dai Science China Life Sciences (2022)Download PDF Sections Figures References Abstract Introduction Results Di...