This chapter provides the fundamental structural map of the spinal cord of the principal laboratory research animal, the mouse, and describes issues and procedures that are used in preparation of mouse spinal cord sections. The sections of mice spinal cord displayed in the atlas were stained either...
Cell type atlases of the mouse spinal cord have been published in recent years but have not been integrated together. Here, we generate an atlas of spinal cell types based on single-cell transcriptomic data, unifying the available datasets into a common reference framework. We report a ...
According to the classification of the Allen Brain Atlas, the adult mouse CNS consists of four major structures, defined by their tissue organization and function: the cerebrum, brainstem, cerebellum, and spinal cord (see table below for more detail). CNS structure Organization/substructure Functions...
2003). Conditional KO targeting floxed Ctnnb1 exons 3–6 with Cre recombinase under the control of the neural specific Brn4 promoter showed decreased size of the spinal cord compared to wild-type embryos, additionally ventricles were missing at E12. Lower proliferation and increased apoptosis (by...
Identification of early RET+ deep dorsal spinal cord interneurons in gating pain. Neuron 91, 1137–1153 (2016). Article CAS PubMed PubMed Central Google Scholar Heintz, N. Gene expression nervous system atlas (GENSAT). Nat. Neurosci. 7, 483 (2004). Article CAS PubMed Google Scholar ...
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(Fig.1b–d, Supplementary Fig.2a, band Supplementary Data1). The spatial transcriptome atlas covered the majority of tissue and organs at this stage, including the brain cerebrum, spinal cord, respiration tract systems, gastrointestinal tract systems, circulation system, bone, skin, gonad, etc.,...
The spinal cord: a Christopher and Dana Reeve Foundation text and atlas. (Academic press, 2009). 20. Battaglia, G. et al. Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of ...
Screenshot of mouse brain atlas Neuroanatomy of the mouse brain Ischemia/hypoxia stroke model View all Publications 01/ 09 previous slide next slide TOP PAPER In vivo imaging in experimental spinal cord injury – Techniques and trends Brain and Spine ...
Finally, we sought to characterize the impact of ex vivo activation on the interpretation of results from two common scRNA-seq study types: unbiased characterization of complex tissue (atlas datasets) and case–control studies. First, examination of the cell annotations from two atlas studies that ...