This classification scheme, which we also applied to the mouse portion of the registry (Fig.3), is intended to provide a useful high-level framework. However, the current cCRE classification scheme does not attempt to explicitly dissect complex multi-element modules. A notable subset (17%) of...
Inferring causality from time-series data poses considerable challenges; conventional methods of network reconstruction offer a static characterization of the network topologies. For example, correlation-based methods [5,6], matrix-based methods such as least-squares, principal component regression (PCR) ...
To generate SARS-CoV-2 viral particles Vero E6 (ATCC# CRL-1586) cell monolayers were maintained in DMEM (Sigma-Aldrich; D5671) supplemented with 10% heat inactivated fetal bovine serum (Cytiva; sh30910.03). Flasks were inoculated with a dilution of 1:100 of SARS-CoV-2 USA-WA1/2020 isola...
Chromosome 4 (117–281) Balancer Screen.A. The balancer regions used in this screen (red) and in a previously published screen (dark gray) are shown. Genotyping microsatellite markers are shown in red. Base pairs refer to Ensembl v51.B. The mating scheme used for the chromosome 4 (117–...
Dysplasia is considered a key transition state between pre-cancer and cancer in gastric carcinogenesis. However, the cellular or phenotypic heterogeneity and mechanisms of dysplasia progression have not been elucidated. We have established metaplastic an
(1:300, Cat# 71-5800, Lot# SH257822; Invitrogen, Waltham, MA). Primary antibodies for another series included rat anti-glial fibrillary acidic protein (1:2500, AB5804, Millipore, Lot # TA265137) or goat anti-Iba1 (1:1000, PA5-18,039, Lot #TI2638761, SJ2467805; ThermoFisher, ...
Biochemical networks are often described through static or time-averaged measurements of the component macromolecules. Temporal variation in these components plays an important role in both describing the dynamical nature of the network as well as provid
Finally, we would like to acknowledge funding from a CIHR Foundation Grant 159920 to BH and RM, an NSERC Discovery Grant 238992-17 to BH, an NIH R01DE019638 to RM, BH, JC, AL, and WD, an NIH U01DE028729 to BH and OK, NIH R35-DE026602 to OK, NIH R01HL138659 ...
(WFD), and the NCI-sponsored Mouse Models of Human Cancer Consortium (MMHCC) with U01 CA84239 (RJC), U01 CA84227 (WFD), U01 CA98013 (JG), U01 CA105417 (DWT), R24 DK 064403 (BJA), T32 HL07382-28 (WJ), The authors thank Susan Kasper and Ritwick Ghosh for performing stathmin...
Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEF- FTDS) Study was made possible through the support of the U.S Department of Health and Human Services (DHHS) and the National Institute on Aging (NIA)/National Institute of Neurological Disorders and Stroke (NINDS) Grant U01...