When the K14 OVA transgenic mice are crossed with the OT-I mice they no longer serve as targets for the OT-I CD8+ T cells from the OT-I mice. This paradox is due to peripheral tolerance that is exhibited by the double Tg mice. I will discuss these two models and describe studies ...
NKT-like cells from β2m−/− mice exhibited high cytotoxic effects on tumor cells in vitro [16]. NK1.1+CD8 T cells from OT-I mice performed rapid and vigorous killing of tumor cells, while the NK1.1− cytotoxic T lymphocyte (CTL) population failed to exhibit potent antitumor ...
Fig 1: The role ofSIRT5in the expansion and survival of CD8+ T cells aftersecondary infection. (A) Schematic representation of LM-OVAinfection.Sirt5+/+ andSirt5−/− OT-1 cells are co-transferred intoCD45.2+ naïve recipients followed by LM-OVAinfection. On day 40 after primaryinfect...
Inflammatory infiltrates in K14-sOVA/OT-I DTg ear buds comprised CD8+ T cells and were present before birth To determine whether inflammation in the ear was caused by endogenous OT-I cells, cryosections taken from ear buds of DTg pups on days 1, 2, and 3 after birth were stained for ...
CD4 helper T cells and CD8 cytotoxic T cells are the two principal T cell lineages in the mammalian immune system. Although distinct in phenotype and function, CD4 and CD8 T cells arise in the thymus from bi-potential, CD4+CD8+double-positive (DP) progenitors. CD4/CD8 lineage choice is cr...
To assess whether expression of the shuffled reporter gene fragments in Tol mice resulted in tolerance toward the parental non-shuffled reporter proteins, CD8+Ly5.1+OT-I T cells—specific for the OVA257–364peptide—were transduced with a retrovirus encoding the green-to-red photo-switchable report...
产品名称: Immortalized Mouse Dendritic Cells (MutuDC1940) 产品型号: T0528产品展商: ABM产品价格: 0.00 元 产品文档: 无相关文档 简单介绍 Immortalized Mouse Dendritic Cells (MutuDC1940) T0528 永生化小鼠树突状细胞(MutuDC1940)上海 安徽 合肥 ABM细胞库Immortalized...
A recent publication [39], reported that an intact signal peptide on dengue virus E protein (ER-targeted E protein) enhanced the immunogenicity for CD8+ T cells and generated superior antibody responses when expressed from the immunogenic recombinant vaccine vector Vaccinia Ankara. The present ...
Together, our study highlights that HLA-I/hTAP-LMP mice are an improved model for studying antigen presentation of HLA-I molecules and their related CTL responses. Human leukocyte antigen class I (HLA-I) molecules that present antigenic peptides to CD8+ T cells and trigger the cytotoxic T ...
Tumors of GPR182−/− mice also contained significantly more CD8+ T cells producing effector cytokine IFN-γ (Fig. 3g) and Granzyme B (GzmB) (Fig. 3h), indicating an improved effector T cell function. Consistently, YUMM1.7 tumors from GPR182−/− mice had higher frequencies of ...