a, UMAP representation of ATAC chromatin accessibility profiles from 19,145 single cells from mouse cortex at P1, P7 and P21, color-coded by major cell type. Left: UMAP plots with cell distribution by age.b, UMAP representation of ATAC chromatin accessibility profiles from 15,919 single cells ...
In fact, a transcriptome-wide rescue effect48 was also observed in most cell types of PS19 mice with PGRN reduction (Fig. 2d). Please note that a slope of 1 in these correlation plots reflects full rescue of DEGs. Furthermore, enrichment analysis focusing on GABAergic and oligodendrocyte ...
Myc-immunoreactive cells were co-stained using anti-beta III tubulin (neuron-specific marker), anti-PLP1 (oligodendrocyte marker), anti-GFAP (astrocyte marker), and anti-CD31 (endothelial marker) primary antibodies, and anti-goat IgG Alexa Fluor 594 and anti-chicken IgY Alexa Fluor 594 ...
Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord Development, 134 (2007), pp. 285-293 CrossrefView in ScopusGoogle Scholar Bayer and Altman, 1987 S.A. Bayer, J. Altman Directions in neurogenetic gradients and patterns of anatomi...
a-o, Subcluster spatial maps on representative sample slices for astrocytes (a), oligodendrocytes and oligodendrocyte precursor cells (b), microglia and perivascular macrophages (c), ependymal cells, choroid plexus epithelial cells and subcommissural organ hypendymal cells (d), olfactory inhibitory neu...
resolution overview of the data; we obtained 33 distinct cell types (Fig.2e): oligodendrocyte precursor cells (OPCs), mature oligodendrocytes (mtOLG1–mtOLG4), olfactory ensheathing glia (OEGs), astrocyte restricted precursor (ARP) cells, mature astrocytes (ASC1–ASC3), ependymal cells (EPCs)...
a, UMAP showing human M1 SNARE–seq2 data, labelled by cell subclass and AC cluster (colours). Astro, astrocyte; Car3, CAR3 gene; CT, corticothalamic cell; ET, extratelencephalic cell; IT, intratelencephalic cell; micro, microglia; NP, near-projecting; oligo, oligodendrocyte; OPC, oligodend...
coupling between oligodendrocytes and oligodendrocyte precursor cells (OPCs), whereas STICRE14showed stronger coupling between oligodendrocytes, OPCs and astrocytes (Fig.1e). Notably, 37.2% of STICRE10clones contained cells of a single class, compared with 62% of STICRE14-descent clones (Fig.1f)...
(Fig.5a, c), suggesting apoptotic cells. To confirm a broad loss of myelin, we also probed for myelin- and oligodendrocyte-associated proteins, which we found to be reduced (Fig.5a, d–f), suggesting a good fraction of the apoptosis we observed is that of oligodendrocytes73. To provide ...