2 min off, 2 min on, 5 min off, all on a continuous vacuum. The tissue was then rinsed in PB twice at 1 min each at 150 W with the vacuum off, and then exposed to the secondary antibody for 15 min at 200 W for 2 cycles of the following: 4 min on,...
Pdk4 phos- phorylates and inactivates pyruvate dehydrogenase, resulting in the shunting of pyruvate toward lactate production rather than entry in the mitochondrial tricarboxylic acid (TCA) cycle. In tissues such as muscle, metabolic switching from glucose to fatty acid oxidation is mediated by ...
Emerging roles of mitochondrial functions and epigenetic changes in the modulation of stem cell fate Chensong Zhang Yang Meng Junhong Han Cellular and Molecular Life Sciences (2024) Devo-Aging: Intersections Between Development and Aging Carlos Giovanni Silva-García GeroScience (2023) Disruption ...
2017). In keeping with a nuclear phenotype, susceptibility to DNA damage or the induction of genes for cell cycle re-entry and transition from G1 to S phase (downstream of mitochondrial stress and normally leading to apoptosis in neurons) has also been shown to be proportional to the CAG ...
Cytoplasmic TDP-43 accumulation drives changes in C-bouton number and size in a mouse model of sporadic Amyotrophic Lateral Sclerosis. Mol Cell Neurosci. 2023;125:103840. https://doi.org/10.1016/j.mcn. 2023.103840. 58. Sanchez-Rivera FJ et al. Mitochondrial ...
Compared to 3-month-old animals, the aged mice also showed a marked accentuation of the mitochondrial pathology as revealed by COX staining. Note the presence of multiple fibers with strongly diminished sarcoplasmic and/or increased subsarcolemmal enrichment of enzyme staining. c In addition to ...
Although still largely unknown, PPAR-γ agonists are expected to ameliorate memory impairment in AD by several mechanisms. Animal studies have demonstrated that PPAR-γ agonists inhibit neuroinflammation, improve mitochondrial function and synapse plasticity, and alleviate tau hyperphosphorylation26,39,46. ...