Interleukin 6 (IL6) and p53 are linked by mutual regulatory mechanisms and are both upregulated in aging. The aim of this study was to evaluate the effects of aging and IL6 on expression of p53 in the mouse heart. Male C57BL6/J wild-type and IL6 knockout mice at...
Tonsawan P, Dylewski J, Lewis L, Blaine J. Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton. Am J Physiol Cell Physiol. 2019;317:C1048-C1060pubmedpublisher Li W, Qu G, Choi S, Cornaby C, Titov A, Kanda N,et al. Targeting...
Skeletal muscle regulates substrate choice according to demand and availability and pyruvate dehydrogenase (PDH) is central in this regulation. Circulating interleukin (IL)-6 increases during exercise and IL-6 has been suggested to increase whole body fat oxidation. Furthermore, IL-6 has been reporte...
et al. Generation of the floxed allele of the SIP1 (Smad-interacting protein 1) gene for Cre-mediated conditional knockout in the mouse. Genesis 32, 82–84 (2002). Article CAS PubMed Google Scholar Aliberti, J. et al. Essential role for ICSBP in the in vivo development of murine ...
we repeated the same analysis in differentiated HoxB8 neutrophils carrying a genetic knockout of eitherJunBorCebpβ. CEBPB showed upregulation in inflamed neutrophils as well as increased regulatory activity. In addition, JUNB, which plays an important role in the inflammatory response of neutrophils9...
S5e–f). Impairment of autophagy by 3-MA or using primary microglia with BECN1 knockout (Tamoxifen-treated BECN1flox/flox·CX3CR1CreERT2 cultures) on the other hand, abolished spermidine-mediated effects (Additional file 1: Fig. S5g–i). Therefore, we concluded that spermidine exerts ...
Thus, the sporadic expression of the target gene better resembles that in human liver cancer in comparison to the traditional transgenic or knockout mouse models. Second, the injection is performed in 6- to 8-week-old mice, thus not inducing any effect on mouse embryonic development. Third, ...
Mdx/utrn−/− double knockout mice (DKO) exhibit most of the clinical signs of DMD patients, such as short stature, kyphosis, limb weakness and breathing problems by 6 weeks of age [22]. All DKO mice succumb to premature death by 20 weeks of age. Compared to senescent mdx mice, ...
The delta 6 desaturase knock out mouse reveals that immunomodulatory effects of essential n-6 and n-3 polyunsaturated fatty acids are both independent of a... et al.The delta 6 desaturase knockout mouse reveals that immunomodulatory effects of essential n-6 andn-3 polyunsaturated fatty acids ...
1. A transgenic knock-out mouse comprising disruption in the endogenous serotonin 5-hydroxytryptamine 6 (5-HT6) receptor gene, wherein said disruption has been introduced into its genome by homologous recombination with a DNA targeting construct in an embryonic stem cell such that the targeting con...