W. Chen, IL-6 signaling blockade increases inflammation but does not affect muscle function in the mdx mouse. BMC Musculoskelet. Disord. 13, 106 (2012).Kostek, M.C.; Nagaraju, K.; Pistilli, E.; Sali, A.; Lai, S.H.; Gordon, B.; Chen, Y.W. IL-6 signaling blockade increases ...
This work uses the model of Batf3 deficiency to confirm early reports of cDC1s as a source of IL-12 during innate immune responses in mice. Article CAS PubMed PubMed Central Google Scholar Askenase, M. H. et al. Bone-marrow-resident NK cells prime monocytes for regulatory function ...
Sevoflurane increases the level of serum IL-6, which activates STAT3 and the infiltration of CD11b+ myeloid cells into the lung. Interruption of IL-6/JAK/STAT3 pathway by a JAK inhibitor AZD1480 reverses the pro-metastatic effect of sevoflurane and the associated increase of both activated ...
CD8+ T cells, gamma δ T cells, B cells, dendritic cells and eosinophils, and plays a vital role in key function of the immune system, tolerance and immunity, primarily via its potent stimulatory activity for T cells.Thus, IL-2 may be a key cytokine in the natural suppression of autoimm...
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6 (IL-6) and soluble IL-6 receptor (sIL-6R) improved symptomatic and neuropathological progression in wobbler mice (Ikeda et al.1996). It has been suggested that IL-6/sIL-6R complex might act on motor neurons through activation and homodimerization of gp130 (Ikeda et al.1996). In a ...
Comparing the IL-22 coding sequence from five mouse strains revealed one missense variation resulting in Asn (DBA/2 and BALB/c) instead of Ser (AKR, 129, FVB, C57Bl/6) at position 84 in the aa sequences, in addition to some silent nucleotide polymorphisms [16]. In addition to Il22,...
characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 produ...
For example, in a recent preliminary report, it has been shown that intrabiliary injection of activated forms of AKT and Yap, together with Sleeping Beauty transposase, followed by bile duct ligation and IL-33 stimulation, resulted in ICC formation in mice (American Association for the Study of...
These studies indicate that an administration of a large dose of IL-1 results in a dramatic decrease in serum primarily through the inhibition of release from the . The results also indicate the induction of a prolonged state due to the unresponsiveness to TSH via a postreceptor mechanism. ...