HLA genes are highly polymorphic, allowing them to fine-tune the adaptive immune response. HLAs corresponding to MHC class I (HLA-A, B, and C) present small peptide antigens from inside the cell, approximately 8 to 10 amino acids in length, to CD8+ T lymphocytes in order to activate a...
The major histocompatibility complex (MHC) class II subregion contains several subclasses of genes. The classical class II genes, HLA-DP, DQ, and DR homologues, present antigens directly to CD4{sup +} T cells. HLA-DM homologues facilitate the efficacy and transport of antigens to the cell ...
immunodeficiency virus infectious disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-A (major histocompatibility complex, class I, A); HLA-B (major histocompatibility complex, class I, B); and HLA-C (major histocompatibility complex, class I, ...
Mouse spleen FFPE sections from both viremic and aviremic conditions, as determined by the plasma viral load, were evaluated using the CosMx SMI instrument, with staining performed using a 1000-plex panel of human genes along with five custom viral probes. Fit-for-purpose validation revealed a ...
Selected TCGA PanCancer Atlas studies were retrieved from cBioPortal84,85,86 and queried for cases which contained gene mutations in IFNγ pathway (IFNGR1, IFNGR2, JAK1, JAK2, and STAT1), antigen presentation pathway (HLA-A, HLA-B, HLA-C, B2M, TAP1, and TAP2), or individual genes as...
Isolated from the embryonic day 14 CD-1 mouse spinal cord. MN-sc are cryopreserved at P0 and delivered frozen. Each vial contains >1 x 106 cells in 1 ml volume. | CD1…
(Fig.1band Extended Data Fig.1a,b), consistent withSiglechexpression10,17. We reasoned that enhanced specificity could be achieved by harnessing intersectional genetics, driving expression of a reporter under the control of two genes coexpressed only in pDCs. We aimed for activation bySiglech-...
The G46-6 monoclonal antibody specifically binds to HLA-DR, a major histocompatibility complex (MHC) class II antigen. HLA-DR antigens are encoded by genes within the Human Leukocyte Antigen (HLA) Complex located on chromosome 6. HLA-DR is a transmembrane heterodimeric glycoprotein composed of ...
The THX mouse huBCR repertoire mirrored that of humans. Indeed, THX mouse huCD19+IgM+B cells expressed huVHDJH-Cμ transcripts with probabilistic VHgene usage, that is, reflecting the genomic representation of human VHgenes (huIgH locus haploid complement consists of 36–49 functional VHgenes ...
Transduction with 5 × 1010 viral genome equivalents of an AAV serotype 2/8 chimera established a chronic HBV infection in a mouse strain carrying human leucocyte antigen A2/DR1 (HLA-A2/DR1) transgenes. In all AAV2/8-HBV-transduced mice, HBsAg, HBeAg and HBV DNA persisted in serum for ...