H. Registration of a 3D mouse brain atlas with brain microstruc- ture data. Neurocomputing. 2003, V. 5254, P. 307-312. https://doi.org/10.1016/ S0925-2312(02)00793-2.Koh W., McCormick B. H. Registration of a 3D mouse brain atlas with brain microstructure data. Neurocomputing. ...
The obtained 3D-model is then used for getting 2D-images of brain in arbitrary section-plane. We use this approach for automatic annotation of brain structures with the aid of Allen Brain Atlas which is available in electronic form. 展开 ...
这种系统和标准化的方法允许将单个实验的空间配准到一个共同的三维(3D)参考空间中,从而产生一个全脑连接矩阵。一个计算模型可以深入了解连接强度分布、对称性和其他网络特性。虚拟束状图显示了相互连接的区域之间的三维拓扑。皮层-丘脑通路分析显示了平行通路的分离和整合。 Allen Mouse Brain Connectivity Atlas 是一个...
We have shown that our method generates results comparable to an expert neuroscientist and is significantly better than reconstruction-first approaches. Code and sample dataset are available at sites.google.com/view/brain-mapping. 展开 关键词: 2D to 3D Allen Mouse Brain Atlas Markov random field ...
The female mammalian brain exhibits sex hormone-driven plasticity during the reproductive period. Recent evidence implicates chromatin dynamics in gene regulation underlying this plasticity. However, whether ovarian hormones impact higher-order chromatin
The mammalian brain relies on neurochemistry to fulfill its functions. Yet, the complexity of the brain metabolome and its changes during diseases or aging remain poorly understood. Here, we generate a metabolome atlas of the aging wildtype mouse brain f
组织清除方法,如iDISCO+,通常与使用单光子激发显微镜的快速3D成像相结合,如LSFM6,7,10。在用荧光团标记的透明组织内,光片荧光显微镜通过用薄平面的光11激发对切片进行成像。LSFM的主要优点是一次照亮单个光学切片,该切片内分子的所有荧光都被激发,从而最大限度地减少了光漂白。此外,对整个光学切片进行...
A brain atlas is necessary for analyzing structure and function in neuroimaging research. Although various annotation volumes (AVs) for the mouse brain have been proposed, it is common in magnetic resonance imaging (MRI) of the mouse brain that regions-o
A new frontier has been reached in both neuroscience and genetics. The expression of each of the roughly 22,000 genes of the mouse genome has been mapped, at cellular resolution, across all major structures of the mouse brain. This achievement is part of the Allen Brain Atlas project. Leine...
While the roles of parenchymal microglia in brain homeostasis and disease are fairly clear, other brain-resident myeloid cells remain less well understood. By dissecting border regions and combining single-cell RNA-sequencing with high-dimensional cytome