Conclusions In conclusion, we have successfully established three AML cell lines in humanized mice, allowing for detailed analysis of tumor growth and tissue infiltration. Utilizing the HIS mice model, our research aims to enrich understanding of AML, paving the way for the development of novel ...
Runt-related transcription factor 3 (RUNX3, AML2), a member of the Runt family of transcription factors, plays an important role in the suppression of gastric epithelium cell proliferation (1), dorsal root ganglia neurogenesis (2), and T cell differentiation (3,4). RUNX3 is also involved ...
Besides, CDK4 inhibition has been shown to enhance the apoptosis of FLT3 inhibitors in the AML cell lines [22]. AMG 925(1) is a novel potent and selective FLT3/CDK4 dual kinase inhibitor (IC50 values of 1 and 3 nmol/L, respectively) [24]. AMG025 was discovered by structural ...
(huBM-sc)-like niche and observed that AML MLL-AF9+and ALL BCR-ABL+patient cells were efficiently implanted, maintaining an immature primitive cell-like phenotype in the huBM-sc ecotype compared to the murine bone marrow (mBM) niche[79]. Later, based on the discovery that human bone ...
replicates per cell line, was analysed using MaGECK44 and this revealed 465, 1624 and 1798 depleted genes (FDR < 0.25) for d6, d10 and d12 ME-Transformed cells respectively, in line with the number of drop-outs obtained using an equivalent gRNA library on multiple AML cell lines43....
Low expression of PHF6 inhibits the proliferation of AML cells To further verify the role of PHF6 in AML, we used shRNA to knock down the PHF6 gene in two human AML cell lines containing MLL::AF9 rearrangement (MOLM13 and THP1). We confirmed the knockdown status of PHF6 in MOLM13 ...
AML12 mouse cell|AML12 CELLS小鼠正常肝复苏细胞系 基本信息 更多信息 中文名称: AML12 CELLS小鼠正常肝复苏细胞系 中文同义词: AML12 CELLS小鼠正常肝复苏细胞系;AML-12 CELLS小鼠肝复苏细胞系 英文名称: AML12 mouse cell 英文同义词: AML12 mouse cell CAS号: 分子式: 分子量: 0 EINECS号: 信息...
(Extended Data Fig.4c). They also encompassed lymphoid cells and a cluster of myeloid cells, but with a low MFI (Extended Data Fig.4d). The pDCs represented 81.5 ± 6% of tdT+splenocytes (Extended Data Fig.4e). The individual contribution of other phenotypic cell clusters to the ...
The expression of ETV6/CBFA2 (TEL/AML1) is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologic disease in vivo. Cancer Genet Cytogenet 2001; 130: 93–104. CAS PubMed Google Scholar Ford AM, Palmi C, Bueno C, Hong D, Cardus P, ...
. Mutations in IDH1 are also implicated in cancer. Originally mutations in IDH1 were detected in an integrated genomic analysis of human glioblastoma multiforme. In addition to being mutated in diffuse gliomas, IDH1 has also been shown to harbor mutations in human acute myeloid leukemia (AML)....