Motor neurone disease (MND), the commonest clinical presentation of which is amyotrophic lateral sclerosis (ALS), is regarded as the most devastating of ad... D Bäumer,K Talbot,MR Turner - 《Journal of the Royal Society of Medicine》 被引量: 88发表: 2014年 ...
Motor neurone disease (MND) is a fatal neurodegenerative disease of unknown aetiology. Malnutrition is a common occurrence and an independent risk factor for worse prognosis. However, it remains unclear whether provision of enteral nutrition (EN) through a gastrostomy tube offers any survival advantage...
Motor neurone disease (MND) is an adult-onset neurodegenerative disease which leads inexorably via weakness of limb, bulbar and respiratory muscles to deat... PJ Shaw,C Wood-Allum - 《Clinical Medicine》 被引量: 86发表: 2010年 Nutritional advice and treatment by dietitians to patients with amy...
definetheclinicalsyndromesencounteredinfrontotemporaldementia-motorneurondisease. Introduction Reportsofdementiainpatientswithmotorneuron diseasehaveappearedintermittentlyintheliterature since100-year-olddescriptionsofemotionallabilityin bulbar-onsetcases.Gradually,themorespecific associationwithfrontotemporaldementiawas...
A.I is funded by the Motor Neurone Disease Association, The Darby Rimmer Foundation, Rosetrees Trust, Alzheimer’s Research UK, Spastic Paraplegia Foundationand, MND Scotland and The NIHR Maudsley Biomedical Research Centre. A.A-C is an NIHR Senior Investigator (NIHR202421) and has received ...
particularly as initial clinical presentation is often lateralised. We note that there is some evidence of asymmetrical TDP-43 pathology in FTLD (without ALS) and Alzheimer’s disease [75], but such asymmetry was not found in two cases of ALS-FTLD [39]. The precise variation of ALS patholog...
In 2003 the Motor Neurone Disease (MND) Association, together with The Wellcome Trust, funded the creation of a national DNA Bank specific for MND. It was anticipated that the DNA Bank would constitute an important resource to researchers worldwide and significantly increase activity in MND genetic...
Amyotrophic lateral sclerosis (ALS) displays considerable clinical and genetic heterogeneity. Machine learning approaches have previously been utilised for patient stratification in ALS as they can disentangle complex disease landscapes. However, lack of independent validation in different populations and tissue...
Each motoneurone is depolarized during ipsilateral burst activity and inhibited during contralateral activity (Fig. 1, Grillner et al., 1987, 1988a,b). The inhibition is produced by contralateral interneurones (CCIN), which produce inhibitory postsynaptic potentials (IPSPs) utilizing glycine as ...
Two types of neurone in the rat ventral tegmental area and their synaptic inputs. J Physiol 450: 2144–2149. Obeso JA, Rodriguez-Oroz MC, Chana P, Lera G, Rodriguez M, Olanow CW (2000). The evolution and origin of motor 455–468. Kapusta DR, Chang JK, Kenigs VA (1999). Central...