The term motor neuron disease encompasses a spectrum of disorders in which motor neurons are the lost. Importantly, while some motor neurons are lost early in disease and others remain intact at disease end-stage. This creates a valuable experimental par
Comparison of inhibitory motoneuron supplies in,adecapod crustacean,bhexapod walking legs and scorpion inhibitory motoneurons (c). Thorax and walking leg of crab (a)and locust (b) are outlined at thetop, respectively, with leg articles labelled. The corresponding pairs of antagonistic muscles are ...
To compare laminar positioning in M1 and MTG, we estimated the relative cortical depth from pia for each neuron on the basis of layer dissection and average layer thickness46. Integrating Cv3 snRNA-seq datasets across species To identify homologous cell types across species, we used Seurat’s ...
The spatial maps of motor neuron activity corresponding to the time at which each hotspot reached a maximum (centre) are laid over the schematics of the spinal cord. b, Colorplots show the spatiotemporal maps of motor neuron activity underlying locomotion in M6 (n = 55 gait cycles), ...
Expression of the neuronal marker MAP2 was also observed 8 weeks after transplantation of hiLGEP cells with approximately 50.3% ± 9.4% of zsGreen-labelled-cells positive for MAP2 (Fig.6B&B’). To confirm the ability for transplanted hiLGEPs to generate MSNs, sections were co-labelled for zsG...
Twenty-four hours after the last treadmill exercise session, 12 rats were randomly selected from each group; rats were anaesthetised with chloral hydrate solution (3.5 mL/kg, i.p.) and fixed in a stereotaxic apparatus (RWD, Shenzhen, China). Striatal neuron firing activity was recorded using...
We previously showed the rate of change of the accumulation rate\({\upsilon }_{i}\left(t\right)\), given by\({\Delta }_{i}^{{{\rm{CB}}}\left(t\right)\)is represented in the delta epoch, the period of time for each neuron in which the reinforcement learning error signal occurs...
Thus, this procedure (Fig. 1c) produces a low efficiency of motoneuron differentiation and is limited to high-density aggregate cultures for neuronal differentiation and maturation. Temporal control of patterning impacts MN differentiation. The weak response of cells to RA and SHH patterning was ...
Ring neuron-specific Ca2+influx has been used as a proxy to measure their neuronal activity in response to an external sensory cue35. Thus, we carried out ex vivo activity-related GCaMP Ca2+-imaging54of ring neurons in response to a graded temperature ramp from 20 to 35 °C and back to...
(small arrow). Scale bars: M 1 μm; N 0.2 μm.gElectron micrograph of a principal neuron in the posterior hypothalamus of a Gfa2-CGG99 mouse that shows the nucleolus (single asterisk) and an intranuclear inclusion (double asterisks) within the nucleus (nu).hHigher magnification of ...