Ever since loss of survival motor neuron (SMN) protein was identified as the direct cause of the childhood inherited neurodegenerative disorder spinal muscular atrophy, significant efforts have been made to reveal the molecular functions of this ubiquitously expressed protein. Resulting research demonstrated...
motor neuron- a neuron conducting impulses outwards from the brain or spinal cord efferent neuron,motoneuron,motor nerve fiber nerve cell,neuron- a cell that is specialized to conduct nerve impulses efferent,efferent nerve,motor nerve- a nerve that conveys impulses toward or to muscles or glands ...
It is a standing puzzle why each neuron needs to express multiple innexins66. The results of this study suggest that UNC-7 and UNC-9 in AVA do not associate with innexins in other neurons indiscriminately but rather in a cell-specific manner to form molecularly and functionally different gap...
The term upper motor neuron is commonly used in reference to corticospinal or corticonuclear cell bodies and their axons. Other neurons, such as rubrospinal or reticulospinal neurons, can also be included under the strict definition of this term. Corticospinal neurons are also called pyramidal neuro...
To determine if the toxic effect of mutant glial cells was the consequence of a specific activity within this cell type rather then a general property of any cell overexpressing the SOD1G93A mutation, we plated motor neuron preparations on mouse embryonic fibroblasts (MEFs) prepared from SOD1G93...
To compare laminar positioning in M1 and MTG, we estimated the relative cortical depth from pia for each neuron on the basis of layer dissection and average layer thickness46. Integrating Cv3 snRNA-seq datasets across species To identify homologous cell types across species, we used Seurat’s ...
The term motor neuron disease encompasses a spectrum of disorders in which motor neurons are the lost. Importantly, while some motor neurons are lost early in disease and others remain intact at disease end-stage. This creates a valuable experimental par
Neuron 2017, 95, 436–446. [Google Scholar] [CrossRef] [Green Version] Wollesen, B.; Wildbredt, A.; Van Schooten, K.S.; Lim, M.L.; Delbaere, K. The effects of cognitive-motor training interventions on executive functions in older people: A systematic review and meta-analysis. Eur...
As in the central nervous system, peripheral nervous pathways are made up of neurons (that is, nerve cell bodies and their axons and dendrites) and synapses, the points at which one neuron communicates with the next. The structures commonly known as nerves (or by such names as roots, rami...
Motor neuronsare comprised of the lowermotor neuroncell body, which originates in thebrain stemor spinal cord and terminates in the skeletal muscle, and theupper motor neuron, which originates inmotor cortexof the brain and terminates in the spinal column or the medulla. Unlike thelower motor ...