On the other hand, this structural key can be optimized for the compounds present in the database to be investigated. Hence, fingerprints were developed to overcome the shortcomings of structural keys. A fingerprint is a boolean array, but in contrast to a structural key the meaning of any ...
In subject area: Biochemistry, Genetics and Molecular Biology A protospacer adjacent motif is a 2–6-base pair DNA sequence immediately adjacent to the DNA sequence targeted by the type I, type II and type V CRISPR-Cas effector complexes. ...
2,3. In a network-based description, species are represented by nodes and their trophic interactions are represented by directed links, pointing from prey to predator2,4,5. Much work has been devoted to understanding the origin and meaning of the particular trophic interaction patterns observed...
SISMA is an exact, enumerative algorithm, meaning that it finds all the motifs conforming to the specifications. It does so in two stages: first it discovers all the possible component simple motifs, then combines them in a way that respects the given constraints. We developed SISMA mainly ...
Deciphering cis-regulatory elements or de novo motif-finding in genomes still remains elusive although much algorithmic effort has been expended. The Markov chain Monte Carlo (MCMC) method such as Gibbs motif samplers has been widely employed to solve the de novo motif-finding problem through sequen...
On the meaning of 'loser' motif in the early novels of 419 generation 419 ' (intellectuals)'. , . , ' ' 10 . '' 1960 ' ' . , . ' ' . , .\n419 genera... Kim,Kun-woo - 《Journal of Modern Korean Literature》 被引量: 0发表: 2007年 An ultra-sparse code underlies the ...
8b). Unexpectedly, the c-Src 531X mutant, despite having a phosphorylable c-terminal Tyr 530, lacked also the capacity to autophosphorylate on this residue, meaning that residues 531 to 536 are required for c-terminal autophosphorylation. Fig. 8: A c-terminal palindromic phospho-motif controls...
[C|G]), meaning that a number of variants of this sequence are potentially present in theB. xylophilusgenome (Fig.1a; Table1). We analyzed each of the variants individually but found no patterns of association with specific gene classes (not shown). One such variant at position 5 (T) ...
(Table5) so that the binding site sequence information derived from TRANSFAC database can be used as input to SVM classifiers for NM prediction. Although the numerical values assigned to nucleic acids do not carry any biological meaning, they were used in our analysis for the purpose of ...
In addition, we successfully obtained cells with ~ 100% EGFP expression by fluorescence-activated cell sorting, meaning that, the mock-vector control aside, all test HSC populations were ~ 100% positive for the expression of each CR as well. These cells were subjected to downstream assays ...