Objective: Macrophages are among the most abundant cells in the colon tumour microenvironment, and there is a close relationship among monocytes, macrophages and the gut microbiota. Alterations in the gut microbiota are involved in tumour development, but the underlying mechanisms remain unclear. We ...
For surfaces presenting Fab′VLA-4 or YEILDV, both of which may both bind to a cell's VLA-4 receptor, the Star:VLA4 surface showed a greater number of adherent monocyte/macrophages. This result suggests that the Fab′ had a higher affinity to the cell receptor than a corresponding ...
Once infected by obligate intracellular pathogens, monocytes/macrophages release cytokines that activate natural killer (NK) cells. NK cells in turn produc... EM Bluman,KJ Bartynski,BR Avalos,... - 《Journal of Clinical Investigation》 被引量: 261发表: 1996年 IL-1β regulates CXCL8 release an...
Recent studies have revealed that CMS4 CRC have a higher expression of inflammation-related pathways, suggesting a strong association between inflammation and stromal activation5,6,9,10. Thrombospondin-1 (THBS1) is a matricellular protein that is highly expressed in inflammatory processes and has vari...
Agents which increase cyclic AMP intracellular level could be of interest for reducing cholesteryl ester accumulation in macrophages.doi:10.1016/0006-291X(87)90459-1N.E. HoutiaJ C MazièreC MazièreM AuclairJ PolonovskiElsevier Inc.Biochemical & Biophysical Research Communications...
It is phagocytosed by immune cells, such as monocytes and macrophages. The precise mechanisms that initiate bacterial uptake have not yet been elucidated. Participation of C3, CR3, class A scavenger receptors and mannose receptor in bacterial uptake have been already reported. However, contribution...
Fc gamma receptor (Fc gamma R) clustering on monocytes/macrophages results in phagocytosis and inflammatory cytokine production, which serve to eliminate antibody-opsonized targets and activate neighboring immune cells. Toll-like receptor 2 (TLR2), which recognizes a range of both bacterial and fungal...
Furthermore, while TLR-2 and -4 stimulation of M1 macrophages primarily triggered pro-inflammatory cytokines and lipid mediators, persistent stimulation (16 h) of human M2 macrophages induced a coordinated upregulation of 5- and 15-LO-2 expression. This was accompanied by a marked increase in ...
The analysis of cells from the IL-23-injected ears of Flt3l À / À mice showed similar numbers of MHC-II þ LCs and MHC-II þ þ LCs in the epidermis, and monocytes, moDDCs and macrophages in the dermis as compared with WT mice, but, as expected, significantly fewer cDCs,...
B cells and macrophages pursue a common path toward the development and progression of chronic lymphocytic leukemia The development and progression of chronic B-cell tumors depend on a complex microenvironmental network of cells that include monocyte-derived macrophages. In chronic lymphocytic leukemia (CL...