Objective: Macrophages are among the most abundant cells in the colon tumour microenvironment, and there is a close relationship among monocytes, macrophages and the gut microbiota. Alterations in the gut microbiota are involved in tumour development, but the underlying mechanisms remain unclear. We ...
2n, o). Because THBS1 has been shown to have a potential regulatory effect on myeloid lineages18, we examined myeloid cell populations including dendritic cells (DC), monocytes, neutrophils, and tumor-associated macrophages (TAMs) (Supplementary Fig. 2p); however, we observed no change in ...
Neutrophils and macrophages are present locally, and DCs that are present at the site of infection partially also arise from immature monocytes [67]. In addition to phagocytosis and antigen presentation to induce the adaptive immunity (T-cell and B-cell activation), neutrophils can degranulate to...
For surfaces presenting Fab′VLA-4 or YEILDV, both of which may both bind to a cell's VLA-4 receptor, the Star:VLA4 surface showed a greater number of adherent monocyte/macrophages. This result suggests that the Fab′ had a higher affinity to the cell receptor than a corresponding ...
pertussis AC+ PT− mutant secreting a recombinant PT toxoid (21, 22) still blocked the M-CSF-driven differentiation of monocytes into macrophages to the same extent as an infection by the B. pertussis WT bacteria. Hence, the differentiation block was largely due to action of the secreted ...
MacrophagesAcute lung inflammationLipopolysaccharideMultiparameter flow cytometryCorticosteroidBackground We have previously reported the presence of novel subpopulations of pulmonary monocyte-like cells (PMLC) in the human lung; resident PMLC (rPMLC, HLA-DR+CD14++CD16+cells) and inducible PMLC (iPMLC, ...
Lipopolysaccharide MDMi: Monocyte-derived microglia-like cells (induced) MDMa: Monocyte-derived macrophages MDDCs: Monocyte-derived dendritic cells NLRP3: NOD-leucine rich repeat and pyrin containing protein 3 γH2AX: Phosphorylated histone H2AX
Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat Rev Immunol. 2014;14(6):392–404. Article CAS PubMed Google Scholar Wolf AA, et al. The ontogeny of monocyte subsets. Front Immunol. 2019;10:1642. Article CAS PubMed PubMed Central Google Scholar Auffray C, et...
(N = 3; mean ± SEM is shown) tumor-associated macrophages (TAMs), which have fea- tures of alternatively activated M2 macrophages [30] and contribute to the suppression of anti-cancer T cell-mediated immune responses, in part through the expansion of regula- tory T cells (Tregs...
et al. Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny. Nat. Rev. Immunol. 14, 571–578 (2014). 14. Hadeiba, H. et al. Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance. Immunity 36, 438–450 (2012)....