We have compared the phenotype of the promonocytic THP-1 cell line after various protocols of differentiation utilising VD3and PMA in comparison to primary human monocytes or monocyte-derived macrophages (MDM). Both stimuli induced changes in cell morphology indicati...
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whole-body irradiation/bone-marrow transplantation. The literature contains conflicting observations about whether microglia, including in the retina, increase expression of these markers in neuroinflammation. We show that monocyte-derived macrophages have elevated expression of these surface markers, not micro...
Kolak et al., "Increased expression of the macrophage markers and of 11尾-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte- derived macrophages, is associated with liver fat in human obesity," International Journal of Obesity, vol. 31, no. 10, pp. 1617-1625, 2007....
Monocytes and macrophages belong to the mononuclear phagocyte system and are derived from macrophage/dendritic cell progenitors in the bone marrow [69]. While monocytes are also formed in the liver and spleen [70, 71, 72], the view that monocytes are derived from the bone marrow has been esta...
Monocyte-derived macrophages from Zebu (Bos taurus indicus) are more efficient to control Brucella abortus intracellular survival than macrophages from Eur... and Santos, R.L.: Monocyte-derived macrophages from Zebu (Bos taurus indicus) are more efficient to control Brucella abortus intracellular ...
Monocyte-derived alveolar macrophages (Mo_AMs) are increasingly recognised as potential pathogenic factors for idiopathic pulmonary fibrosis (IPF). While scRNAseq analysis has proven valuable in the transcriptome profiling of Mo_AMs, the integration analysis of multi-omics may provide additional dimensions...
Successful organ transplantation requires an optimal innate immune response to avoid tissue injury. In this issue of Immunity, Braza etal. (2018) inhibit pro-inflammatory activation of infiltrating graft macrophages using nanotechnology tools to promote immune tolerance, leading to long-term transplant ...
Monocytes containing replication-competent virus may reseed tissue macrophage reservoirs when they exit the blood and differentiate into monocyte-derived macrophages (MDM). Thus, we have developed an MDM quantitative viral outgrowth assay (MDM-QVOA) for HIV. We have quantitated the replication-...
2b). After 48 h in culture with M-CSF, cMoP could no longer be distinguished in flow cytometry from monocyte-derived macrophages with respect to the typical MΦ-surface markers CD11b and F4/80 (Fig. 3b). Fig. 3: cMoP-derived MΦ keep their potential to form MGC and show a ...