Monoclonal antibodies were the first successful targeted anti-cancer therapeutics in the modern era. In the 1970s elucidation of hybridoma and molecular biology technologies established mechanisms to produce and
Histopathological findings include granuloma- tous inflammation in the dermis extending into subcutaneous fat. The granulomas are alternating with foci of collagen necrobiosis and are associated with epithelioid and foamy histiocytes in addition to lymphocytes, plasma cells, and multinucleated giant cells,...
"46-3351 was used in Flow cytometry/Cell sorting to indicate that high-fat diet-induced obesity might exacerbate allergic airway inflammation through mechanisms involving ILC2s and ILC3s." Authors Everaere L,Ait-Yahia S,Molendi-Coste O,Vorng H,Quemener S,LeVu P,Fleury S,Bouchaert E,Fan ...
It plays a role in lipid metabolism, inflammation, and atherosclerosis, and is involved in the recognition and uptake of various ligands such as oxidized low-density lipoproteins, long-chain fatty acids, and apoptotic cells. CD36 is also implicated in the pathogenesis of malaria. The protein ...
Cancer is one of the diseases in which monoclonal antibodies play an increasingly important role. But, there are other conditions, includingautoimmune diseases, that benefit from monoclonal antibody therapy. Drug Names Monoclonal antibody drugs are often recognized by the suffix "mab"—the abbreviation...
Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation. "17-2069 was used in Flow cytometry/Cell sorting to outline a novel mechanism for regulating adipose tissue homoeostasis and inflammation through metabolic reprogramming...
In obese patients, adipose tissue contains crown-like structures formed by hypertrophic adipocytes surrounded by macrophages [7]. The interaction between macrophages and adipocytes promotes obesity-associated chronic inflammation and further pathological alterations. As an endocrine organ, adipose tissue ...
Adipocytehypertrophy is associated with lysosomal permeability both in vivo and in vitro: role inadipose tissue inflammation. Am J Physiol Endocrinol Metab. 2012 Sep 1;303(5):E597-606. doi: 10.1152/ajpendo.00022.2012. Epub 2012 Jun 26. PubMed PMID: 22739104.17. Akbarshahi H, Menzel M, Pos...
The role of tenofovir-based HIV pre-exposure prophylaxis in preventing HBV infection among men who have sex with men: insights from China ArticleOpen access Explore related subjects Discover the latest articles and news from researchers in related subjects, suggested using machine learning. ...
Myeloid lineage immune cell, containing a number of membrane-bound proteins including CD52, secrete a variety of cytokines and enzymes that result in inflammation. As some of these substances occur in secretory vesicles that appear granular, the process of secretion is sometimes called degranulation....