Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light ...
tissue-specific IFPs. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an...
Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light ...
As scientists learn more about the mechanism of diseases—and the role that specific antibodies play in them—there are expected to be many more monoclonal antibodies licensed for use by the FDA. There are hundreds of experimental or investigation antibodies in various stages of testing or developme...
Multiple risk factors, including genetic mutations and background, family and reproductive history, aging and exposures to toxins, contribute to breast cancer risk. However, the global rates of breast cancer incidence and mortality have continuously increased in the past few decades [2], suggesting ...
Our ideas are based on the concept that selective removal of toxic Aβoligomers is important in immuno- therapy since non-toxic Aβplays a physiologically important role in synapse communication30 and regulation of glucose metabolism31. We developed the conformation-specific monoclonal antibody...
Abstract Preclinical animal models play a significant role in the understanding of the pathogenesis of paraproteinemias which is central to the development of effective strategies for the management of these diseases. This chapter discusses the large variety of animal models which are available for stud...
Finally, because Tau oligomers are suspected to have an important role in disease propagation (11) and because previous studies indicated that phosphorylated Tau accumulated in detergent-resistant membrane domains or lipid rafts during disease progression (33), we evaluated whether the 130-kDa oligomers...
FRAP1 (mTOR) is a serine/threonine kinase that plays a critical role in cellular growth and proliferation. Perturbations in the mTOR/PI3-kinase/AKT pathway are associated with numerous forms of cancer. FRAP1 is also the target of rapamycin and its analogues, which are currently used as immunos...
Alzheimer's disease (AD) is characterized by the progressive loss of cognitive function and the accumulation of amyloid beta (Aβ) plaques in regions associated with learning and memory. While Aβ plaques were once thought to play a central role in the pathogenesis of AD, a growing body of ...