Monoclonal B-cell lymphocytosis (MBL) is defined by the presence of a monoclonal B-cell population in the peripheral blood (PB) at a concentration of < 5 x 10(9)/l and no signs or symptoms of a lymphoproliferative disorder. In around 75% of cases, the immunophenotype of the clonal B-...
de Tute R, Yuille M, Catovsky D, Houlston RS, Hillmen P, Rawstron AC. Monoclonal B-cell lymphocytosis (MBL) in CLL families: substantial increase in relative risk for young adults. Leukemia . 2006;20(4):728–729.de Tute R,Yuille M,Catovsky D. Monoclonal B-cell lymphocytosis (MBL) ...
Monoclonal B-cell lymphocytosis (MBL) is a condition that resembles chronic lymphocytic leukemia (CLL) but does not meet the critera for CLL, and does not require treatment. However, CLL requiring treatment develops at the rate of 1.1% per year. The definition of CLL includes >5000 CLL-...
1587 Monoclonal B-cell lymphocytosis (MBL) with an immunophenotype consistent with marginal zone origin (MBL-MZ), that can be either CD5 or CD5+ but atypical for CLL, and also lacking an IGH/CCND1 translocation, is an increasingly recognised entity with poorly understood biological background ...
Several studies have demonstrated impaired immune cell functions in chronic lymphocytic leukemia (CLL) patients, contributing to tumor evasion and disease progression. However, in CLL-like monoclonal B cell lymphocytosis (MBL) studies are scarce. Herein, we characterized the immune environment in 62 ...
Monoclonal B-cell lymphocytosis (MBL) with normal lymphocyte counts is associated with decreased numbers of normal circulating B-cell subsets.Little is known about the distribution of normal lymphoid cells and their subsets in the peripheral blood (PB) of subjects with monoclonal B-cell lymphocytosis...
CLL-like monoclonal B-cell lymphocytosis (MBL) shares a unique immunophenotype with chronic lymphocytic leukemia (CLL), and represents the vast majority of clonal B-cell expansions found in the peripheral blood of otherwise healthy subjects. Along with the improvement of laboratory techniques and the...
摘要: High-count monoclonal B cell lymphocytosis (MBL) with a chronic lymphocytic leukemia (CLL) phenotype is a well-known entity, featuring 1–4% annual risk of progression towards CLL requiring treatment...关键词: Monoclonal B cell lymphocytosis Chronic lymphocytic leukemia Non-Hodgkin’s lymphoma...
B cell analysis of ethnic groups in Mali with differential susceptibility to malaria. 4. Cytometry. Part B, Clinical cytometry Chronic lymphocytic leukaemia (CLL) and CLL-type monoclonal B-cell lymphocytosis (MBL) show differential expression of molecules involved in lymphoid tissue homing. ...
High-grade B-cell lymphoma of the peritoneum as a result of transformation of a CD5-negative monoclonal B lymphocytosis population in a patient with myelodysplastic syndrome treated with 5-azacytidineMonoclonal B lymphocytosis (MBL) is characterized by asymptomatic monoclonal expansion of <5.0 x 109/...