monoamine oxidase inhibitor (redirected fromMonoamine oxidase inhibitors) Thesaurus Medical Encyclopedia monoamine oxidase inhibitor n.Abbr.MAOI Any of a class of antidepressant drugs that block the action of monoamine oxidase in the brain, thereby allowing the accumulation of monoamine neurotransmitters such...
Monoamine oxidase inhibitors (MAOIs) were among the first licensed pharmacological treatments for patients with depression but over time have fallen out of mainstream clinical use. This has led to a loss of clinician training opportunities and reduced availability of MAOIs for prescribing. This ...
1. The principal routes of metabolism of the following monoamine oxidase inhibitors (MAOIs) are described: phenelzine, tranylcypromine, pargyline, deprenyl, moclobemide, and brofaromine. 2. Acetylation of phenelzine appears to be a minor metabolic pathway. Phenelzine is a substrate as well as an...
Themonoamine oxidaseinhibitors are an old-established class of antidepressant; their use is much more limited than the tricyclics because they are both less effective and more toxic. The antidepressant action of these drugs has been directly related to their main pharmacological action—the inhibiti...
The aim of this article is to synthesize informations about monoamine oxidase inhibitors drugs (MAOI) used in the treatment of depression. General informations on monoamine oxidase (MAO) and its kinetic properties are presented. MAO is an enzyme that degrades catecholamines and their 3-methoxy deriv...
Revisiting monoamine oxidase inhibitors for the treatment of depressive disorders: A systematic review and network meta-analysis Background: Monoamine oxidase inhibitors (MAOIs) were the first class of modern antidepressants; however, they are under-utilized as compared to the newer ... R Suchting,...
This suggests that other inhibitors (either known or unknown) may be more significant contributors to total inhibitory activity than has yet been established, and deserve closer examination. Copyright 2016. Published by Elsevier B.V. 展开 关键词: Tobacco dependence Monoamine oxidase inhibitors Tobacco ...
MAO-A and MAO-B are two isoforms of mitochondrial monoamine oxidase (MAO) that are responsible for the deamination of various monoamine substrates. For example tyramine and dopamine are metabolised by both MAO isoforms. MAO-A specifically metabolises noradrenaline and serotonin, while MAO-B metaboli...
2.2. Inhibitors of Monoamine Oxidases (MAO A and MAO B) Figure 1 shows examples of irreversible and reversible inhibitors of MAO. 2.2.1. Irreversible Inhibitors Three classes of compounds that inactivate MAO are represented in currently approved drugs. Hydrazines The first antidepressants were ...
Monoamine Oxidase Inhibitors This group of drugs—monoamine oxidase inhibitors (MAOIs)—inhibits the intracellular enzyme responsible for breaking down monoamine neurotransmitters. Monoamine oxidase has two isoforms: MAO-A and MAO-B. MAO-A deaminates dopamine, norepinephrine, epinephrine, melatonin, and ...