Monkeypox virus Clade IbMpox virus Clade IbReal-time PCRdiagnostic testMonkeypox virus (MPXV) is an emerging zoonotic pathogen with complex epidemiology necessitating rapid diagnosis and distinguishing between clades and subclades. The emerging Clade Ib lac...
Monkeypox virus (MPXV) is an emerging zoonotic pathogen with complex epidemiology necessitating rapid diagnosis and distinguishing between clades and subclades. The emerging Clade Ib lacks the genomic region used in the Clade I-specific assay from the Centers for...
The resurgence of monkey pox (mpox) virus clade Ib, which was declared a global health emergency in August 2024, poses a significant threat worldwide. Initially contained through public health measures, the increased transmissibility of clade Ib strains compared with that of previous strains has ...
Monkeypox virus (MPXV), which causes disease in humans, has for many years been restricted to the African continent, with only a handful of sporadic cases in other parts of the world. However, unprecedented outbreaks of monkeypox in non-endemic regions have recently taken the world by surpris...
Molecular evolution of 2022 multi-country outbreak-causing monkeypox virus Clade IIb. iScience. 2024;27(1):108601. Article CAS PubMed Google Scholar Musuka G, Moyo E, Tungwarara N, Mhango M, Pierre G, Saramba E, et al. A critical review of mpox outbreaks, risk factors, and ...
which had spread globally in 2022, has a survival rate of over 99.9 per cent and is endemic to West Africa. Five countries in Africa (Burundi, DRC, Kenya, Rwanda and Uganda) and three countries outside of Africa (Sweden, Thailand, India) have reported clade Ib monkeypox virus (MPXV) ...
(C,D)). In summary, young rabbits, with their immature immune systems, are more susceptible to MPXV infection via respiratory droplets compared to adult rabbits. This observation is consistent with the recent epidemic, where the clade Ib variant of MPXV predominantly affects children through ...
Globally, there are two major poxvirus outbreaks: mpox, caused by the monkeypox virus, and lumpy skin disease, caused by the lumpy skin disease virus. While vaccines for both diseases exist, there is a need for improved vaccines. The original vaccines used to eradicate smallpox, which also ...
Clade IA has a higher mortality than clade IB [5]. Clade IB is spreading from DR Congo through central Africa and has been reported in Uganda and Rwanda. The mpox deaths in Africa caused by clade 1B are seen mainly in children (78%). Mpox has also been reported to cause stillbirths...
MPXV is a double-stranded DNA virus with a large genome (200 kilobase) encoding for 191 proteins. There are 2 main clades (distinct genetic lineages or subgroups) of the virus that have evolved from a common ancestral virus. Clade I is endemic to Central African countries and is ...