MONKEYPOXPREGNANT womenPREGNANCYDEATH rateSTILLBIRTHABRUPTIO placentaeIn African countries where mpox (monkeypox) is endemic, infection is caused by two genetically related clades—Clade I (formerly Congo Basin), and Clade IIa (formerly West Africa), both of which are potentially life-thr...
Figure 1.Typical clinical manifestations and pathological injury in adult rabbits with intravenous MPXV inoculation. Adult rabbits were intravenously mock-infected or infected with 106.5PFU of MPXV through the ear vein in 1 ml DMEM and then sacrificed on 2, 6 and 10 dpi. (A) Schematic dia...
Monkeypox virus (MPXV) infection of the prairie dog is valuable to studying systemic orthopoxvirus disease. To further characterize differences in MPXV clade pathogenesis, groups of prairie dogs were intranasally infected (8 × 103 p.f.u.) with Congo Basin (CB) or West African (WA) MPXV...
The global spread of monkeypox virus has raised concerns over the establishment of novel enzootic reservoirs in expanded geographic regions. We demonstrate that although deer mice are permissive to experimental infection with clade I and II monkeypox viruses, the infection is ...
Monkeypox virus (MPXV) is a zoonotic poxvirus long endemic in West and Central Africa. Outbreaks, first the global spread of clade II outside Africa in 2022, and since 2023 the accelerating spread of clade I in central Africa, point to MPXV adaptations that pose the risk of it becoming ...
The resurgence of monkey pox (mpox) virus clade Ib, which was declared a global health emergency in August 2024, poses a significant threat worldwide. Initially contained through public health measures, the increased transmissibility of clade Ib strains compared with that of previous strains has ...
monkeypoxneutralizing antibodiesvaccinesvaccinia virusSince early May 2022, some monkeypox virus (MPXV) infections have been reported from countries where the disease is not endemic. Within 2 months, the number of patients has increased extensively, becoming the most considerable MPXV outbreak described...
Clade IIb A.3 monkeypox virus: an imported lineage during a large global outbreakStephen D WoolleyRebecca LesterKaren DevineClare E WarrellNatalie GrovesMichael B J BeadsworthThe Lancet Infectious Diseases
Monkeypoxanimal modelclade IIb variantpathogenicityrabbitThe 2022 monkeypox outbreak involved rapid global dissemination, prompting research into animal models for the monkeypox virus (MPXV), including non-human primates and mice. However, studies utilizing rabbits as models remain limited. In this ...
Monkeypox virus (MPXV) is an emerging zoonotic pathogen with complex epidemiology necessitating rapid diagnosis and distinguishing between clades and subclades. The emerging Clade Ib lacks the genomic region used in the Clade I-specific assay from the C...