Reed, S.V. , Haddon, M.E. & Denson, K.W.E. ( 1994 ) An attempt to standardise the APTT for heparin monitoring using the PT ISI/INR system of calibration: results of a 13 centre study . Thrombosis Research , 74 , 515 – 522 ....
OBJECTIVE: To assess the effect on the desired activated partial thromboplastin time (APTT) of altered practice in the laboratory control of heparin treatment. METHODS: Descriptive study of the number of APTTs in the desired range (DR) in 1987 (historical controls) and in 1992/1993. In the ...
Unfractionated heparin (UFH) has unstable pharmacokinetics and requires close monitoring. The activated partial thromboplastin time (aPTT) test has been used to monitor UFH therapy for decades in Korea, but its results can be affected by numerous variables. We established an aPTT heparin therapeutic ...
The conventional monitoring of heparin treatment is carried out by activated partial thromboplastin time (aPTT) and plasma heparin measurements as anti-Xa activity. The anticoagulant properties of unfractionated heparin depend on the presence of a specific pentasaccharide sequence with high affinity to ant...
211: EVALUATION OF ANTI-XA AND APTT MONITORING OF HEPARIN IN ADULT PATIENTS RECEIVING ECMO SUPPORTdoi:10.1097/01.ccm.0000528230.71573.b0Arnouk, SerenaAltshuler, DianaMerchan, CristianZakhary, BishoyPapadopoulos, JohnCRITICAL CARE MEDICINE -BALTIMORE-...
Our purpose was to determine whether the in vitro (or "spiked curve") method for the therapeutic heparin range is an accurate and valid method for heparin monitoring. Many laboratories use the in vitro method for determining the activated partial thromboplastin time (APTT)-based unfractionated hepar...
Use of the activated partial thromboplastin time for heparin monitoring. In phase 1, 102 blood samples were analyzed for bedside and laboratory aPTTs and heparin concentration (used to establish aPTT therapeutic range). In ... Smythe Maureen A.,Koerber John M.,Westley Susan J.,... - 《Ameri...
抗凝血劑一般使用肝素(heparin) • 活化凝血時間(Activatedclotting time,ACT)大約控制在200-250秒之 間 • 或aPTT控制在40-45秒之間 • 如果病人有高危險出血傾向,肝衰竭 患者甚至可不必使用抗凝劑,可用前 稀釋來減少透析器凝固。 適應症(腎臟相關疾病) ...
Therefore, the data do not reflect steady-state heparinization. In HEARTCAT, anti-Xa, aPTT, and ACT discriminated well between the high-dose and low-dose UFH protocol studied. The clear dose-response relationship observed in the current study differs from the results of a previous study by ...
Monitoring the aPTT is mandatory during i.v. unfractionated heparin treatment in patients receiving thrombolytic therapy for AMI. Subtherapeutic aPTTs are associated with lower patency rates at one–two days and the risk of reocclusion is high within the first 48 h 4, 11, 12, 13. In addition...