mRNA transport coupled with translation emerged as a key process of gene expression that targets protein synthesis to specific compartments of cells. In this process, motors act in concert with the cytoskeleton to assemble, stabilize, and transport mRNAs, and this process is also coupled with the ...
During their journey translation of mRNAs is repressed, and it is only activated once the mRNAs reach their final destination [11–15]. In this chapter, we will review recent findings that shed new light on the evo- lution of the molecules involved in translational control of transported mRNAs...
Molecules in focus: Cytosolic phospholipase A(2)-{alpha} Translation initiation factor 4E (eIF4E) binds the 7-methylguanosine cap structure of mRNA and mediates recruitment of mRNA to ribosomes, with the potential of regulating the overall rate of translation and discriminating between differe... ...
Additionally, for a 3D molecule generative model, it is crucial to generate molecules with favourable bindings in the target pockets. This assessment can be approached from two perspectives: binding mode with the pocket (interactions with the pocket) and the ligand’s strain energy, both of which...
Cortical granule exocytosis is important for the block to polyspermy at fertilization in the eggs of most vertebrates and many invertebrates. Cortical gran... S Conner,DL And,G Wessel - 《Molecular Reproduction & Development》 被引量: 174发表: 1997年 Atomoxetine affects transcription/translation of...
11 Protein Synthesis and Translational Control in Saccharomyces cerevisiae I. INTRODUCTION The process of translation in Saccharomyces cerevisiae does not appear to differ fundamentally from the way it occurs in other organisms. Thus, much of what follows represents a comparison of the components and re...
Single-molecule fluorescence microscopy is a powerful technique in the investigation of protein function. Many fundamental cellular processes, including stepping of motor molecules1, DNA replication2, transcription3,4and translation5, or the stoichiometry6and mechanism of action7of membrane receptors, have...
(f) (i) translation (ii) transcription 4 (a) (i) Unwinds the two DNA strands; breaks hydrogen bonds between bases. (Note: those students who have done background reading might talk about 'active' and 'passive' helicases: the 'active' helicases require ATP, e.g. ATPX...
is further complicated by a complex relationship between drug binding and a potentially broad range of altered protein–protein interactions involved in a diversity of cellular processes (e.g. proliferation, differentiation, apoptosis, metabolism, immune response, protein transcription and translation, and...
The analysis was carried out according to international quality guidelines (ISCN 2016: An International System for Human Cytogenetic Nomenclature49) by the “Sächsischer Inkubator für klinische Translation” (Leipzig, Germany). Data availability Data available on request from the authors....