Cortical granule exocytosis is important for the block to polyspermy at fertilization in the eggs of most vertebrates and many invertebrates. Cortical gran... S Conner,DL And,G Wessel - 《Molecular Reproduction & Development》 被引量: 174发表: 1997年 Atomoxetine affects transcription/translation of...
elongation factor TutranslationGTP-hydrolysisprotein dimersenergy metabolismA new experimental design has been used to determine the number of GTPs hydrolysed per peptide bond in EF-Tu function in a poly(U)-translation system. We find that two GTPs are consumed for every amino acid incorporated ...
(2013) Orthoformimycin, a selective inhibitor of bacterial translation elongation from Streptomyces containing an unusual orthoformate. ACS Chem Biol 8: 1939–1946. Mazzetti, C., Ornaghi, M., Gaspari, E., Parapini, S., Maffioli, S., Sosio, M., and Donadio, S. (2012) ...
During E2~dID ubiquitination of proteins occurs in extracts. To assess if substrates suggested by E2~dID are also ubiquitinated by APC/C in living cells, we performed quantitative diGly proteomics comparing the mitotic ubiquitinome in the presence and absence of APC/C activity (Fig.3b). To rapi...
Fundamental problems faced by the protocells and their modern descendants include how to go from one phenotypic state to another; escape from a basin of attraction in the space of phenotypes; reconcile conflicting growth and survival strategies (and ther
activate the Ras–Raf signalling pathway33; in the cytoplasm, where they interact with mTOR34; or in the nucleus, where they are Akt substrates35and repress transcription of Yy136. As all of these latter molecules are involved in myelination, we asked if Prohibitins engaged in axo-glial ...
In modern cells, SUMIs such as PolyP, PHB and polyamines are involved in both growth and survival and hence are well-placed to mediate transitions between the two states. Moreover, these SUMIs are also involved in energy metabolism. Their simple, essential nature and their universality therefore...
The term “expression” refers to the production of a protein as a result of transcription of the gene encoding it in a messenger RNA molecule (mRNA), and its subsequent translation into a polypeptide chain. As known by experts in the art, the expression levels of genes are affected by reg...
function of Fra-2 expression in breast cancer exist. So far, only one study has shown that in breast cancer, overexpression of Fra-2 is associated with a more aggressive tumour phenotype, suggesting that Fra-2 may be involved in breast cancer progression in vivo (Milde-Langosch et al.2008)...
In addition to the well-known role in detoxification of ethanol, SCADs are also involved in synthesis and degradation of fatty acids, steroids, and some prostaglandins, and are therefore implicated in a variety of disorders such as lipid storage disease, myopathy, SCAD deficiency, and certain ...