At the same time, we are eating an increasingly energy-dense diet and are also moving far less than our ancestors. These three factors are poison for brown fatcells: They gradually cease to function and eventually even die. On the other hand, the number of severely overweight people worldwid...
In mammals, selectins are adhesion molecules with a trans-membrane glycoprotein that are expressed on leukocytes and activated epithelial cells [88]. The vertebrate selectin family consists of L-selectin, E-selectin and P-selectin and these are mostly involved with leukocyte homing and migratory ...
Lipids are the main constituents of cell membranes; the major functions of lipids are transportation of ions and signals across the cell membrane. Various types of lipids, such as glycerophospholipids (GPLs), sphingolipids, sterol lipids, saccharolipids, waxes, and fat-soluble vitamins are found ...
Aside from their immunosuppressive properties, which are mediated via interaction with calcineurin, members of the FKBP family show a canonical peptidyl-prolyl cis-trans isomerase (PPIase) or rotamase activity and regulate various physiological functions, including protein folding, stability9–11, histone...
TNIK may provide therapeutic benefit in multiple pathologies in which fibrosis may be implicated. In agreement with this hypothesis, TNIK was independently predicted as a disease target associated with multiple hallmarks of aging15and as a regulator of lipid metabolism in aged and/or high-fat diet-...
A production technology of triglyceride-molecule-reconstructed plastic fat comprises the following steps: a) preparing according to raw material ratio; b) distillation; c) dehydration: dehydrating the distilled composite grease to have a water content of 0.5% or less; d) addition of a composite ...
Coenzyme Q10 is a fat soluble vitamin-like substance produced by the human body. It is necessary for proper functioning of many organs and for basic functioning of cells. It is found throughout the body. Coenzyme Q10 is used both as a food supplement and as an important antioxidant.It is ...
Mutations resulting in decreased activity of p53 tumor suppressor protein promote tumorigenesis. P53 protein levels are tightly regulated through the Ubiqu
02 March 2016 Small Molecule Inhibited Parathyroid Hormone Mediated cAMP Response by N–Terminal Peptide Binding Amit Kumar1,2, Monika Baumann2 & Jochen Balbach2,3 Ligand binding to certain classes of G protein coupled receptors (GPCRs) stimulates the rapid synthesis of cAMP through G prote...
Effect of Sioc145 on cell viability. (PDF 92 kb) Supplementary information, Figure S2 Sioc145 enhances p58-YFP signal independent of protein synthesis. (PDF 205 kb) Supplementary information, Figure S3 The effect of Sioc145 ontrans-Golgi protein Galt. (PDF 318 kb) ...