A parallelism can be found between the behaviour of liquid crystals in materials science and lipids in life science [1]. Both are self-organizing systems. Lipid molecules are the basic building blocks of all biological membranes [2]. They aggregate in aqueous solution into vesicles (liposomes) ...
The effect of adding CHX to DMPC is a thinning of the membrane, thus increasing the area per lipid.doi:10.1016/j.jmgm.2013.12.007Van Oosten, BradMarquardt, DrewKomljenovi?, IvanaBradshaw, Jeremy P.Sternin, EdwardHarroun, Thad A.Elsevier Inc.Journal of Molecular Graphics & Modelling...
Diacylglycerides are commonly found in nature with acyl chains occurring at two adjacent carbons, and are the basis of phospholipid chemistry. Isoprene-Based Lipids The other class of lipid molecules, based on a branched five-carbon structure called isoprene, was first identified via steam ...
We identify βII spectrin as a binding partner of CHL1, and we show that partial disruption of the complex between CHL1 and βII spectrin accompanies CHL1 endocytosis. Inhibition of the association of CHL1 with lipid rafts by pharmacological disruption of lipid rafts or by mutation of cysteine...
lipid,lipide,lipoid- an oily organic compound insoluble in water but soluble in organic solvents; essential structural component of living cells (along with proteins and carbohydrates) nucleic acid- (biochemistry) any of various macromolecules composed of nucleotide chains that are vital constituents of...
Multiomics analysis of naturally efficacious lipid nanoparticle coronas reveals high-density lipoprotein is necessary for their function ArticleOpen access06 July 2023 Main Lp(a) is a genetically determined, independent cardiovascular risk factor that cannot be modified through lifestyle changes, and no ...
Structure of a bacterial dynamin-like protein lipid tube provides a mechanism for assembly and membrane curving. Cell 139, 1342–1352 (2009). Article PubMed PubMed Central Google Scholar Hu, J. & Rapoport, T. A. Fusion of the endoplasmic reticulum by membrane-bound GTPases. Semin. Cell ...
In 1925, Gorter and Grendel 1 found the area of a monomolecular film of extracted lipids at an air–water interface to be twice that of the cell surface area and postulated a lipid bilayer in the membrane. Dervichian and Macheboeuf 2 used similar techniques and obtained a ratio of 1 : ...
Molecule of the Month. TREDAPTIVE (nicotinic acid/laropiprant): a new lipid-modifying therapy for the treatment of LDL-C, HDL-C and triglycerides Felts AS. AS Felts - 《Current Topics in Medicinal Chemistry》 被引量: 38发表: 2008年 The RCSB PDB "Molecule of the Month": Inspiring a ...
Integrins are components of cell-matrix adhesions, and function as scaffolds for various signal transduction pathways. So far no lipid ligand for integrin has been reported. Here we show that a lipid, oxysterol 25-hydroxycholesterol (25HC), directly binds to α5β1 and αvβ3 integrins to act...