研究发现肝细胞中可被OXA上调的YTHDF2在阻碍肝癌进展中发挥了关键作用。肝脏YTHDF2对于维持肝脏的抗肿瘤反应至关重要。在小鼠模型和HCC患者中,肝细胞中YTHDF2的缺失降低了CX3CL1 mRNA的稳定性,损害了CD8+T细胞功能,促进了肿瘤生长。OXA...
Despite the known impact of YTHDF1 on tumor cells, its role in the tumor microenvironment (TME) is less well-documented. Immunotherapy has advanced in treating cancer, yet solid tumors respond at a rate below 30%, largely due to the immunosuppressive nature of the TME [9, 10]. Tumor-...
In vivo studies show that YTHDF1 siRNA delivered via nanoliposomes significantly suppresses HCC growth and enhances the efficacy of sorafenib and Lenvatinib [8]. Despite the known impact of YTHDF1 on tumor cells, its role in the tumor microenvironment (TME) is less well-documented. Immunotherapy...
facilitated by Wtap and Ythdf1, controls the activation of neurotoxic astrocytes, thereby impacting the secondary injury in mouse TBI. Our objective is to identify new molecular targets for treating TBI and contribute to the recuperation of patients and enhanced quality of life ...
A novel mechanism of FTO modulating the progression of endometriosis through mediating the m6A methylation of GEF-H1 in a YTHDF1-dependent manner Xin-Yu Ding, Hua-Ying Zhang, Jia-Hao Chen, Meng-Jie Yang, Zhi-Xiong Huang, Yi-Hong Lei, Qin-Kun Sun, Jian-Bin Bai, Dian-Chao ...
RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2. Hepatology. 2018;67(6):2254–70. Article CAS PubMed Google Scholar Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, et al. A METTL3–METTL14 ...
Recently, m6A modulators, including “writers” (METTL3, METTL14, WTAP and RBM15), “easers” (ALKBH5 and FTO), and “readers” (YTHDF1/2/3, HuR and HNRNPA2B1), have been considered to be essential for regulation of cancer biology, thus, m6A modification in cancers is gradually ...
Non-heme iron and α-ketoglutarate-dependent (Fe/αKG) oxygenases catalyze various oxidative biotransformations. Due to their catalytic flexibility and high efficiency, Fe/αKG oxygenases have attracted keen attention for their application as biocatalyst
The structure includes a shell of DSPE-modified RGD peptides targeting integrin receptors on tumor cells and carboxymethyl mannose targeting CD206 receptors on macrophages, with a core of chitosan adsorbing m6A reading protein YTHDF1 siRNA and chromium nanoparticles (Cr NPs). The approach is ...
International Journal of Molecular Sciences Article Actions of Inonotus obliquus against Hyperuricemia through XOD and Bioactives Screened by Molecular Modeling Tianqiao Yong 1,2,*, Shaodan Chen 1,2, Danling Liang 1,2,3, Dan Zuo 4, Xue Diao 1,2, Chenling Deng 1,2, Yuning Wu 1,2, Hui...