为了理解YTHDF2如何稳定m5C修饰的靶基因,作者发现在一项利用BioID技术研究细胞质亚结构中(stress granule和processing body等)蛋白质互作网络的研究中,11YTHDF2与PABPC1可能互相结合,PABPC1曾被证明可以稳定mRNA的表达量,经典的m5C识别蛋白...
为了理解YTHDF2如何稳定m5C修饰的靶基因,作者发现在一项利用BioID技术研究细胞质亚结构中 (stress granule和processing body等) 蛋白质互作网络的研究中,11 YTHDF2与PABPC1可能互相结合,PABPC1曾被证明可以稳定mRNA的表达量,经典的m5C识别蛋白YBX1也正是通过招募PABPC1实现稳定mRNA的表达。12 有趣的是,在B细胞肿瘤...
Exercise improves cardiac function and metabolism. Although long-term exercise leads to circulating and micro-environmental metabolic changes, the effect of exercise on protein post-translational lactylation modifications as well as its functional relevance is unclear. Here, we report that lactate can re...