Partington, G.ARogers, G.EElsevier Inc.Biochemical & Biophysical Research CommunicationsKemp DJ, Partington GA, Rogers GE. Isolation and molecular weight of pure feather keratin mRNA. Biochem Biophys Res Commun. 1974 Oct 8; 60 (3):1006–1014....
In cancer immunotherapy, the most advanced application of mRNA is therapeutic vaccination, which leverages both the capability of mRNA to deliver genetic information and its innate immunostimulatory activity. The latter is particularly important for breaking immune tolerance when cancer-associated self-antige...
In February 2022, Moderna, Inc. and Thermo Fisher Scientific, Inc. announced their strategic collaboration agreement to operate a large-scale manufacturing unit of Moderna’s COVID-19 vaccine in the U.S., along with several other mRNA medicines In May 2022, Agilent Technologies, Inc. collaborate...
Cells possess mechanisms to prevent synthesis of potentially deleterious truncated proteins caused by premature translation-termination codons (PTCs). Here... M Bühler,F Mohn,L Stalder,... - 《Molecular Cell》 被引量: 180发表: 2005年 The NMD mRNA surveillance pathway downregulates aberrant E-cadh...
We have previously reported that altered stability of low molecular weight neurofilament (NFL) mRNA in lumbar spinal cord homogenates in amyotrophic lateral sclerosis (ALS) is associated with altered expression of trans-acting 3′ UTR mRNA binding proteins. We have identified two hexanucleotide motifs...
A representative of three independent experiments is shown. e Triton X-114-based phase separation assay. The detergent (D) and aqueous phase (A) of TGP3 samples treated with indicated enzymes were analyzed by SDS-PAGE and in-gel fluorescence. The molecular weight of home-made fluorescence ...
Many proteins encoded by a single gene exist in more than one sequence variant – called protein isoforms. They arise from alternative splicing during mRNA maturation. Selected exons and introns can be included/excluded from the final mRNA product. ...
Consistent with the findings from the ICON7 dataset, we showed that the infiltrated and excluded tumour-immune phenotypes have similar abundant quantities of CD8+T cells by in situ analysis (Supplementary Fig.5e), and similar CD8 mRNA expression levels by RNAseq (Fig.4c, top). However, they ...
In practice, single base variants in cDNA (mRNA) are considered to be SNPs as are single base insertions and deletions (indels) in the genome. SNPs provide the ultimate/simplest form of molecular markers as a single nucleotide base is the smallest unit of inheritance, and thus they can ...
eleven potential KGs further were screened out. Based on the GEPIA database to test the relative expression of KGs mRNA, it was determined that our proposed KGs (CXCL8, CEMIP, MMP7, CA4, ADH1C, GUCA2A, GUCA2B, ZG16, CLCA4, MS4A12andCLDN1) may be closely related to the occurrence ...