INSULINInsulin travels as well defined band in electropherograms if acetic acid-water 1:2 (v/v) is used as a buffer. Preparations of partially acetylated insulin were analysed by this method. From the results it could be derived that the molecular weight of insulin is 6,000. An improvement...
Our work revealed the presence of all three C9-HRE-related molecular pathologies and developmental stage-dependent size phenotypes in cerebral organoids from C9-ALS/FTD patients. In addition, single-cell RNA sequencing identified changes in cell type abundance and distribution in C9-ALS/FTD organoid...
NAFLD's influence on PCOS was demonstrably mediated by fasting insulin levels, showing a strong correlation (odds ratio 102, 95% confidence interval 101-103; p=0.0004). Furthermore, Mendelian randomization analysis revealed a potentially significant indirect causal effect involving fasting insulin and ...
Adrenaline, angiotensin II, vasopressin, thrombin, insulin, interleukin 1, platelet-derived growth factor (PGDF), TNF-α and epidermal growth factor (EGT) are among the other factors stimulating endothelin secretion. ET-A and ET-B are two types of receptor that are bound with G proteins and ...
Mice lacking Akt2 show normal growth but eventually develop insulin resistance and type 2 diabetes-like syndrome4. Akt3 knockout mice only showed reduced brain size and weight5. Although the role of the endothelial Akt1 isoform has widely been studied in angiogenesis1,6, the role of Akt and ...
Breastmilk contains bioactive molecules essential for brain and cognitive development. While sialylated human milk oligosaccharides (HMOs) have been implicated in phenotypic programming, their selective role and underlying mechanisms remained elusive. He
Molecular radiotherapy combines the advantages of systemic administration of highly specific antibodies or peptides and the localized potency of ionizing radiation. A potential target for molecular radiotherapy is the cell surface antigen CD44v6, which is overexpressed in numerous cancers, with limited expr...
The top of each panel shows Northern blot autoradiograms of CYP7A1, SHP, LRH-1 and LXRα mRNA expression. The bottom of each panel shows respective relative expression levels corrected by a β-actin internal standard. (B) Bile acid–dependent regulation of Shp and Cyp7a1 transcription in ...
of active components. Chitosan has limited solubility in most organic solvents; however, it can be dissolved in acidic water-based solutions, especially when the pH is below 6 [42]. Various parameters, including the molecular weight, degree of deacetylation (DDA), and pH of the solvent, can ...
Coronary microvascular endothelial cells (CMECs) react to changes in coronary blood flow and myocardial metabolites and regulate coronary blood flow by bal