As one of the most common metastatic sites of malignancies, bone has a unique microenvironment that allows metastatic tumor cells to grow and flourish. The fenestrated capillaries in the bone, bone matrix, and bone cells, including osteoblasts and osteoc
Significant changes have occurred in the anthropogenic emissions of many compounds related to the Kyoto and Montreal Protocols within the past 20 years and... BR Miller,RF Weiss,PK Salameh,... - 《Analytical Chemistry》 被引量: 361发表: 2008年 Perfluorocarbons in the global atmosphere: tetrafl...
It contains 4,591,276 molecules in total, filtered by molecular weight in the range from 250 to 350 Daltons, a number of rotatable bonds not greater than 7, and XlogP less than or equal to 3.5. We removed molecules containing charged atoms or atoms besides C, N, S, O, F, Cl, Br,...
The basic premise of this approach is to take advantage of the mouse as a genetic system for the analysis of genetically complex disorders and to then apply that information to the study of human disease. This paper reviews: (1) current concepts concerning the control of body weight in man ...
Breast cancer, the most frequent female malignancy, is often curable when detected at an early stage. The treatment of metastatic breast cancer is more challenging and may be unresponsive to conventional therapy. Immunotherapy is crucial for treating met
The first line of the file must contain a header with desired column names. The dataset has to be organized as follows: i. First column: unique IDs assigned for each mass signal. ii. Second column: a list of experimental or theoretical masses without any adducts, such as Na, K, Br ...
The primer pair APSBF/APSBR was used to amplify a 550 bp fragment using genomic DNA as template. The product was then labeled with digoxigenin-dUTP. The membrane was hybridized with the probe at 42°C for 18 h. After stringent washing and immunological detection, the hybridization bands were...
The danger lies in the fact that detachment of a DVT can cause fatal pulmonary embolism with a high mortality rate; it is a crucial cause of perioperative and unexpected hospital deaths [6, 7]. Low-molecular-weight heparin and vitamin K antagonists, such as warfarin and sulodexide, are ...
We therefore performed a second round of screening by blending structural analogues of donor MTPA-CA (MCZ-CA, MCZ-CA2, MTPA-Br, TPA-BT-Br and ID-BT-Br) with a subset of the CNP acceptors. These dyes possess similar donor–acceptor configurations to MTPA-CA, with arylamines as electron...
Mechanisms of overlapping molecules in cancer and neurodegenerative diseases. (Down) Mutant p53 inhibits the nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2)-mediated antioxidant enzymes, and thus induces reactive oxygen species (ROS) production. Low-molecular-weight (LMW) cyclin E cannot...