The primary structure of the cone-rod homeobox protein (CRX), a member of the OTX-like homeobox protein family, in the rat was deduced from the cDNA nucleotide sequence. The deduced protein consisted of 299 amino acid residues with motifs conserved in mammalian CRXs, and was 98% identical ...
Studies of homoplasy and convergence demonstrate that morphological similarity can sometimes be a poor guide to evolutionary relationships11. While some argue that molecules should invariably have primacy in phylogenetic inference12, morphological and molecular data are often reciprocally illuminating, as shown...
The influence of DNA double-strand break structure on end-joining in human cells. Nucleic Acids Res. 29, 4783–4792 (2001). Article CAS PubMed PubMed Central Google Scholar Chen, S. et al. Accurate in vitro end joining of a DNA double strand break with partially cohesive 3’-overhangs...
Squamous cell metaplasia (SCM) is a frequent epithelial alteration of the human tracheobronchial mucosa. This review pays particular attention to the fact that SCM can mimic esophageal, and in some instances even skin-type differentiation, showing striking similarities not only in morphology but also...
In this review, we will focus on the rodent mPFC and its structure–function relationships with connected brain areas in the context of neurodevelopmental disorders.102,103 One example of a well-defined rodent model for neurodevelopmental disorders is the apomorphine-susceptible and apomorphine-...
True morels (Morchella spp.) are highly valuable and medicinal mushrooms. Saprophytic morels have been cultivated, especially in China and some Western countries, over the last few decades. Türkiye has a rich potential in terms of wild morel diversity,
Therefore, to compensate for these minor challenges maintaining a balance is important. The vast array of bioactive compounds found in medicinal plants continues to be an important resource for drug discovery and development, and structure–activity relationship (SAR) studies are important to understand...
Generalized structure of a tree stem showing orientation of major tissues including outer bark, cambium, sapwood, and heartwood.Photo courtesy of St. Regis Paper Co. Sapwood and Heartwood Young xylem or sapwood conducts sap (primarily water), strengthens the stem, and to some extent serves as...
STAT3 structure and the canonical and non-canonical STAT3 signaling pathways in cancer.ADiagrams of structure and function domains of STAT3 with the posttranslational modification residue sites. STAT3 is composed of an N-terminal domain (NTD), DNA binding domain, linker domain, Src homology 2 domai...
progression of retinoblastoma as well. Besides its role in the cell cycle, pRB plays many additional roles, it regulates the nucleosome structure, participates in apoptosis, DNA replication, cellular senescence, differentiation, DNA repair and angiogenesis. Notably, pRB has an important role as a mod...