receptor. We determined the structure of BmGr9 in complex with one such non-activating sugar,l-sorbose. Although both sugars bind a similar position, onlyd-fructose is capable of engaging a bridge of two conserved aromatic residues that connects the pocket to the pore helix, inducing a conform...
Nature of α and β Particles in Glycogen Using Molecular Size Distributions Glycogen is a randomly hyperbranched glucose polymer. Complex branched polymers have two structural levels: individual branches and the way these branches ... MA Sullivan,F Vilaplana,RA Cave,... - 《Biomacromolecules》 被引...
QM/MM simulations rationalize these results, showing that AaNGT follows a SN2 reaction mechanism in which the acceptor asparagine uses its imidic form for catalysis and the UDP-glucose phosphate group acts as a general base. These findings provide key insights into the mechanism of NGTs and will...
and Segal, D.A.: Molecular mapping of the mouse ob mutation. Submitted, 1991. Frohman, L.A., and Bernardis, L.L.: Effect of hypothalamic stimulation on plasma glucose, insulin, and glucagon levels. Am J Physiol 221: 1596–1603, 1971. CAS PubMed Google Scholar Garthwaite, T.L., ...
The complexes generate by this process are in agreement with the available experimental data [78] and allowed to gather a better understanding of these proteins that are attached to enzymes that can decompose cellulose into glucose units [79]. As in a virtual screening campaign, hundreds or ...
derivatives have been defined (e.g., ‘Glc’ for glucose, ‘GlcNAc’ forN-acetylglucosamine). Typically the short names are derived from the trivial names of the monosaccharides (e.g. ‘Fuc’, systematic name: 6-deoxy-galactopyranose; trivial name: fucose). As already shown, in order to ...
[83] modeled an Al 2O3 mineral surface in contact with the organic compounds stearic acid and glucose. The aim of this work was to study the mechanism by which glucose accumulates in a layer between Al 2O3 and stearic acid, as observed experimentally. The simulations conducted revealed that...
DBP is illustrated because it is among the best-characterized transcriptional outputs of the core clock pathway in liver cells that is directly linked to both sterol and glucose metabolism. In addition to these transcriptional activators, the search for mammalian orthologs of the Drosophila Per gene ...
Adult animals (7 weeks old) of either sex were deeply anesthetized in a slush of frozen extracellular solution containing: 134 mM NaCl, 2.9 mM KCl, 2.1 mM CaCl2, 1.2 mM MgCl2, 10 mM HEPES and 10 mM glucose, with pH 7.8 adjusted with NaOH and osmolarity of 290...
It’s target gene mutations associated in metabolic pathways are a clear characteristic of RCC17. On the other hand, T2D is also a metabolic disease which is characterized by the deregulation of genes, glucose and lipid metabolism18. Insulin resistance also increases the insulin levels, insulin-...