(A) Hierarchical structure of the peripheral nervous system neuronal cell types. Neurotransmitters used by each cell types are indicated by the colored dots next to each leaf. (B) gt-SNE embedding of all related cells demonstrate the diversity and abundance of the different clusters. (C) Dot ...
One can consider the contemporary use of 18F-fluorodeoxyglucose as molecular imaging of hexokinase activity because the accumulation of the radionuclide is due to phosphorylation of deoxyglucose by that enzyme and subsequent trapping of the labeled tracer in the cell. But, much of the conceptual ...
Identification of potential anti-TNBC targets for nomilin The molecular structure of nomilin was shown in Supplementary Fig. 1A-B. Nomilin’s potential targets were screened from the Swiss Target Prediction database, the medicinal chemistry database ChEMBL, and the STITCH database. In general, ...
glucose metabolism in plants, as well as cell growth and elongation [8]. The primary response of crops to drought stress is osmotic regulation [9]. This regulation involves the synthesis and accumulation of osmotic substances, such as amino acids, betaine, and carbohydrates [10]. Water-soluble ...
Structure of human drug transporters OATP1B1 and OATP1B3. Nat Commun. 2023;14(1):5774. https://doi.org/10.1038/s41467-023-41552-8. Article CAS PubMed PubMed Central Google Scholar Sissung TM, Reece KM, Spencer S, Figg WD. Contribution of the OATP1B subfamily to cancer biology and...
Structure of the FKBP12–rapamycin complex interacting with the binding domain of human FRAP. Science 273, 239–242 (1996). Article CAS PubMed Google Scholar Chen, J., Zheng, X. F., Brown, E. J. & Schreiber, S. L. Identification of an 11-kDa FKBP12–rapamycin-binding domain within...
As omics technologies evolve, fresh and novel statistical and machine-learning techniques are needed to analyze data while considering the property of and structure of omics data. The most frequent statistical method is the T-test. Receiver Operating Characteristic (ROC) Analysis is frequently ...
[5,6,7,8,9,10,11,12]. The neural correlates of MDD differ in males and females at the level of brain structure [13,14] and potentially cell-type composition [15]. There are strikingly sex-specific transcriptional signatures of depression in corticolimbic brain regions associated with mood ...
Oxidative stress (OS), which impacts lipid metabolic reprogramming, can affect the biological activities of cancer cells. How oxidative stress and phospholipid metabolism (OSPM) influence the prognosis of pancreatic cancer (PC) needs to be elucidated. Th
Rapid and precise detection of waterborne pathogens is critical for effective public health management and environmental safety. Traditional methods for water quality monitoring, considered the “Gold Standard,” are time-consuming, costly, and rely on centralized laboratories and expertise. These methods ...