Molecular Pathways in Cancer Are Increasingly Being ExploitedWayne Kuznar
Molecular pathways: reactive oxygen species homeostasis in cancer cells and implications for cancer therapy. Reactive oxygen species (ROS) are important in regulating normal cellular processes, but deregulated ROS contribute to the development of various human dis... Veronique,Nogueira,Nissim,... - 《...
Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification. Papillary and invasive cancers of the urinary bladder appear to evolve and progress through distinct molecular pathways. Invasion in bladder cancer forebod... P Anirban,Mitra,H Ram,......
The landscape of EGFR pathways and personalized management of non-small-cell lung cancer. Future Oncol 2011;7:519–541. Article CAS PubMed Google Scholar Ciardiello F, Tortora G . EGFR antagonists in cancer treatment. N Engl J Med 2008;358:1160–1174. Article CAS PubMed Google Scholar ...
Colorectal cancer (CRC) is a molecularly heterogeneous disease arising from gradual accumulation of genetic and epigenetic changes. In the last de
The aberrant expression of lncRNAs in prostate cancer has been well-documented and progression rate of tumor cells are regulated via affecting STAT3, NF-κB, Wnt, PI3K/Akt and PTEN, among other molecular pathways. Furthermore, lncRNAs regulate radio-resistance and chemo-resistance features of prosta...
Wee1 kinase as a target for cancer therapy Wee1, a protein kinase, regulates the G2 checkpoint in response to DNA damage. Preclinical studies have elucidated the role of wee1 in DNA damage repair an... S Mueller,DA Haas-Kogan - 《Journal of Clinical Oncology Official Journal of the Ameri...
Given the role of autophagy in facilitating tumor growth, autophagy inhibition has gained wide attention as a potential anticancer therapy. Here, we summarize relevant genetic, preclinical, and clinical studies and discuss the multifaceted role of autophagy in cancer, as well as the prospects of ...
As an internationally recognized journal, Molecular Cancer is dedicated to the innovation of how basic cancer research drives advances in cancer prevention, ...
The activation of the cGAS-STING pathway has tremendous potential to improve anti-tumor immunity by generating type I interferons. In recent decades, we have witnessed that producing dsDNA upon various stimuli is an initiative factor, triggering the cGAS