Molecular pathological analysis of the structure and expression of constituents of the p53 pathway is likely to have value in diagnosis, in prognostic assessment and, ultimately, in treatment of breast cancer.Introduction First described in 1979, and initially believed to be an oncogene, p53 was ...
Cancers are often associated with hypoxia and metabolic reprogramming, resulting in enhanced tumor progression. Here, we aim to study breast cancer hypoxia responses, focusing on secreted proteins from low-grade (luminal-like) and high-grade (basal-like) cell lines before and after hypoxia. We exa...
Breast cancer (BC) is one of the risk factors for EC, but the molecular pathways and core genes shared by these two diseases have not yet been elucidated. In this study, we sought to identify the common molecular pathways and prognostic hub proteins in EC and BC that can be used for ...
and 521,900 women died of breast cancer [1]. Breast cancer is a highly heterogeneous disease. Clinical treatment and prognosis varies greatly between patients. The 2013 St. Gallen International Breast Cancer Conference
Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic featu
1. HER2-18 Determination of HER2-low status in tumors of patients with unresectable and/or metastatic breast cancer in DESTINY-Breast04. 2. HER2-06 Outcome analysis of HER2-zero or HER2-low hormone receptor-positive (HR+...
Breast cancer is a major cause of death in Western women, with a 10% lifetime risk of the disease. Most breast cancers are estrogen-dependent. Molecular therapies for breast cancer have developed rapidly in the past few decades and future treatment strategies are being investigated. The selective...
Ingvarsson S (1999) Molecular genetics of breast cancer progression. Semin Cancer Biol 9: 277-228.Ingvarsson S (1999) Molecular genetics of breast cancer pro- gression. Semin Cancer Biol 9:277-288Ingvarsson S. Molecular genetics of breast cancer progression. Semin Cancer Biol 1999; 9:277-88....
(CC), and molecular function (MF) of common DEGs between primary and metastatic cancerous cells. This analysis was carried out using EnrichR (https://amp.pharm.mssm.edu/Enrichr/), a free online and web-based bioinformatics tool that comprehensively investigates the BP, CC, and MF related to...
EIF4A3-mediated circ_0042881 activates the RAS pathway via miR-217/SOS1 axis to facilitate breast cancer progression Chenxi Ju , Mingxia Zhou & Jing He Comment 21 August 2023 | Open Access Cancer stem cell immunoediting by IFNγ The secretion of interferon gamma (IFNG, best known as...