molecular mechanismGenetic epidemiology has assembled convincing evidence that anxiety and related disorders are influenced by genetic factors and that the genetic component is highly complex, polygenic, and epistatic. Although several genes which may contribute to the genetic variance of anxiety-related ...
Molecular foundation of anxiety disorders. J Neural Transm 108, 717–746 (2001). https://doi.org/10.1007/s007020170048 Download citation Issue DateJune 2001 DOIhttps://doi.org/10.1007/s007020170048 Keywords: Anxiety anxiety disorders genetics gene knockout molecular mechanism. Access this article ...
from the other PERs; all other rates were approximately the same (TableS2). Thus, our model indicates that the potential mechanism by whichPER3SNP variants influence anxiety occurs via the interactions of PER3 with CRY and CKIδ/ε proteins. Although our model does not allow us to test pred...
Cells are continuously exposed to various stress factors that endanger their functionality and thus, their ability to cope with stress. The ability of cells to adapt and survive by restoring homeostasis is an integral component of cellular physiology. However, if the stress is persistent and homeosta...
These cell-surface membrane proteins are promising therapeutic targets for the development of new analgesic drugs for chronic inflammatory pain. Citation: Su YS, Sun WH, Chen CC. Molecular mechanism of inflammatory pain. World J Anesthesiol 2014; 3(1): 71-81 URL: https://www.wjgnet.com/...
Further investigation should be performed to elucidate its mechanism of action on brain morphometry [138]. Moreover, this drug also elevated striatal dopamine, which is independent of impulse flow or exocytosis. Inversely, taurine-evoked upsurge in striatal dopamine was dependent on impulse flow [139...
childhood physical and sexual abuse, emotional neglect, bullying, or early separation from parents, are associated with subsequent onset, severity and chronicity of MDD.26,27Epigenetics is a molecular mechanism that has attracted attention as it helps explain the biological impact of environmental facto...
A. J. Dunn and C. W. Berridge, “Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?”Brain Res. Brain Res. Rev.,15, No. 2, 71–100 (1990).
Serotonin receptor 4 (5-HT4R) plays an important role in regulating mood, anxiety, and cognition, and drugs that activate this receptor have fast-acting antidepressant (AD)-like effects in preclinical models. However, 5-HT4R is widely expressed throughou
of dopamine neurons, and this leads to activation of receptors that are only reached through overlapping dopamine domains from multiple release sites. The third mechanism, firing induced in distal axons by cholinergic interneurons, was only recently discovered [32]. It remains uncertain how it ...