No consistent mechanism of action can be discerned in the variety of complex types of behaviours affected by the anti-anxiety drugs in various tests. All the antianxiety drugs are anti-convulsants and muscle relaxants, "tame" or reduce fighting in aggressive animals, and increase the amount of...
Mood disorders such as depression are accompanied by changes in the structure and function of the prefrontal cortex, cingulate cortex and amygdala (Drevets et al. 2008). In particular, specific connections between these areas are lost (Mayberg 2003) and animal studies suggest that this probably o...
Heiligenstein JH, et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002;27:699–711. ...
In vitro cellular experiments were conducted to screen formulas and elucidate the mechanism of antianxiety and antidepressant action. Additionally, a mouse depression and anxiety model was established to investigate the efficacy and safety of the screened formulation. This research aimed to provide a ...
antidepressant drugsBDNFIL-10interferon-betainterferon-gammamultiple sclerosisThe mechanism of action of interferon (IFN)-beta therapy in multiple sclerosis (MS... K Hamamcioglu,AT Reder - 《Multiple Sclerosis》 被引量: 32发表: 2007年 A case of anorexia nervosa with comorbid Crohn's disease: ben...
As would be expected for drugs with the same mechanism of action, we observed a high correlation in the gene expression signatures across six statins (atorvastatin, fluvastatin, lovastatin, mevastatin, rosuvastatin, and simvastatin) in HA1E cells (Supplementary Fig.4), supported by high pairwise...
How does meclizine work (mechanism of action)? Meclizine may work by blocking the effect of a substance in your body called histamine. How is meclizine supplied (dosage forms)? Meclizine is available as Antivert and generic meclizine in the following dosage forms that are taken by mouth. ...
The antinociceptive activity and mechanism of action of cannabigerol. Biomed. Pharmacother. 2023, 158, 114163. [Google Scholar] [CrossRef] Powles, T.; Poele, R.T.; Shamash, J.; Chaplin, T.; Propper, D.; Joel, S.; Oliver, T.; Liu, W.M. Cannabis-induced cytotoxicity in leukemic ...
clinical studies on the anti-inflammatory mechanism of MEHTCMPs should be combined with modern scientific methods and regulatory methods to further conduct in-depth studies on the material basis, pharmacological mechanism of action, toxicological evaluation, and relationship between structure and efficacy....
In another study, curcumin was administered at doses up to 12 g/day for three months with no apparent toxicity." - Review of the Protective Mechanism of Curcumin on Cardiovascular Disease | 2024 "As an antioxidant, anti-infection, anti-inflammatory, and anti-tumor compound, curcumin has been...